Purpose Because preapproval clinical trials typically exclude pregnant women, the evidence
on drug safety during pregnancy required to inform drug labeling must come from …

Background Opioid agonist therapy is strongly recommended for pregnant persons with
opioid use disorder. Buprenorphine may be associated with more favorable neonatal and …

Introduction: Depression affects 300 million individuals worldwide. While selective serotonin
reuptake inhibitors (SSRI) are one of the first-line pharmacological treatments of major …

Background Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other
antidepressants during pregnancy is associated with an increased risk of congenital cardiac …

Background There has been concern that exposure to lithium early in pregnancy may be
associated with a marked increase in the risk of Ebstein's anomaly (a right ventricular …

Importance The frequency of antipsychotic (AP) use during pregnancy has approximately
doubled during the last decade. However, little is known about their safety for the developing …

OBJECTIVE: To report the prevalence of prescription opioid use and evaluate the trends in a
large cohort of Medicaid-enrolled pregnant women. METHODS: A cohort of pregnancies …

OBJECTIVE: To develop and validate a maternal comorbidity index to predict severe
maternal morbidity, defined as the occurrence of acute maternal end-organ injury, or …

Importance The association between selective serotonin reuptake inhibitor (SSRI)
antidepressant use during pregnancy and risk of persistent pulmonary hypertension of the …

Background Hydroxychloroquine is generally considered safe in pregnancy for the treatment
of rheumatic conditions, but studies have been too small to evaluate teratogenicity …