[HTML][HTML] Tuberculosis and lung damage: from epidemiology to pathophysiology
S Ravimohan, H Kornfeld, D Weissman… - European respiratory …, 2018 - Eur Respiratory Soc
A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …
Physiology and pathophysiology of matrix metalloproteases
T Klein, R Bischoff - Amino acids, 2011 - Springer
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …
based on a conserved mechanism involving activation of an active site-bound water …
Mechanistic links between COPD and lung cancer
AMG Houghton - Nature Reviews Cancer, 2013 - nature.com
Numerous epidemiological studies have consistently linked the presence of chronic
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …
obstructive pulmonary disease (COPD) to the development of lung cancer, independently of …
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis
Background The genetic risk factors for susceptibility to chronic obstructive pulmonary
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
disease (COPD) are still largely unknown. Additional genetic variants are likely to be …
Mediators of chronic obstructive pulmonary disease
PJ Barnes - Pharmacological reviews, 2004 - ASPET
Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …
problem that is now a leading cause of death. COPD is associated with a chronic …
Matrix metalloproteinase-9 in lung remodeling
JJ Atkinson, RM Senior - American journal of respiratory cell and …, 2003 - atsjournals.org
Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4. 24.35)
is an MMP that is present in low quantities in the healthy adult lung, but much more …
is an MMP that is present in low quantities in the healthy adult lung, but much more …
Matrix metalloproteinases in COPD
A Churg, S Zhou, JL Wright - European Respiratory Journal, 2012 - Eur Respiratory Soc
There is considerable evidence that matrix metalloproteinases (MMPs) are up-and/or
downregulated in chronic obstructive pulmonary disease (COPD), particularly in …
downregulated in chronic obstructive pulmonary disease (COPD), particularly in …
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted
KJ Greenlee, Z Werb… - Physiological reviews, 2007 - journals.physiology.org
The matrix metalloproteinases (MMPs), a family of 25 secreted and cell surface-bound
neutral proteinases, process a large array of extracellular and cell surface proteins under …
neutral proteinases, process a large array of extracellular and cell surface proteins under …
MMP12, Lung Function, and COPD in High-Risk Populations
Background Genetic variants influencing lung function in children and adults may ultimately
lead to the development of chronic obstructive pulmonary disease (COPD), particularly in …
lead to the development of chronic obstructive pulmonary disease (COPD), particularly in …
Smad3 null mice develop airspace enlargement and are resistant to TGF-β-mediated pulmonary fibrosis
P Bonniaud, M Kolb, T Galt, J Robertson… - The Journal of …, 2004 - journals.aai.org
Transforming growth factor-β1 plays a key role in the pathogenesis of pulmonary fibrosis,
mediating extracellular matrix (ECM) gene expression through a series of intracellular …
mediating extracellular matrix (ECM) gene expression through a series of intracellular …