GABAA receptor subtype involvement in addictive behaviour

DN Stephens, SL King, JJ Lambert… - Genes, Brain and …, 2017 - Wiley Online Library
GABAA receptors form the major class of inhibitory neurotransmitter receptors in the
mammalian brain. This review sets out to summarize the evidence that variations in genes …

Shared mechanisms of GABAergic and opioidergic transmission regulate corticolimbic reward systems and cognitive aspects of motivational behaviors

O Hosseinzadeh Sahafi, M Sardari, S Alijanpour… - Brain Sciences, 2023 - mdpi.com
The functional interplay between the corticolimbic GABAergic and opioidergic systems plays
a crucial role in regulating the reward system and cognitive aspects of motivational …

GABRB2, a key player in neuropsychiatric disorders and beyond

M Barki, H Xue - Gene, 2022 - Elsevier
The GABA receptors represent the main inhibitory system in the central nervous system that
ensure synaptogenesis, neurogenesis, and the regulation of neuronal plasticity and …

Gabrb2-knockout mice displayed schizophrenia-like and comorbid phenotypes with interneuron–astrocyte–microglia dysregulation

RK Yeung, ZH Xiang, SY Tsang, R Li, TYC Ho… - Translational …, 2018 - nature.com
Intronic polymorphisms of the GABAA receptor β2 subunit gene (GABRB2) under adaptive
evolution were associated with schizophrenia and reduced expression, especially of the …

Meta-analyses of genome wide association studies in lines of laying hens divergently selected for feather pecking using imputed sequence level genotypes

C Falker-Gieske, H Iffland, S Preuß, W Bessei… - BMC genetics, 2020 - Springer
Background Feather pecking (FP) is damaging behavior in laying hens leading to global
economic losses in the layer industry and massive impairments of animal welfare. The …

GABRB2 plays an important role in the lymph node metastasis of papillary thyroid cancer

Y Jin, W Jin, Z Zheng, E Chen, Q Wang, Y Wang… - Biochemical and …, 2017 - Elsevier
Background Thyroid cancer is a common malignant tumor of the endocrine system. Its
incidence has increased continuously worldwide for the past three decades. With advanced …

Highly Recurrent Copy Number Variations in GABRB2 Associated With Schizophrenia and Premenstrual Dysphoric Disorder

A Ullah, X Long, WK Mat, T Hu, MI Khan, L Hui… - Frontiers in …, 2020 - frontiersin.org
Objective Although single-nucleotide polymorphisms in GABRB2, the gene encoding for
GABAA receptors β2 subunit, have been associated with schizophrenia (SCZ), it is unknown …

Association between GABA receptor delta subunit gene polymorphisms and heroin addiction

X Xie, J Gu, D Zhuang, W Shen, L Li, Y Liu, W Xu… - Neuroscience …, 2021 - Elsevier
Evidence suggests that γ-aminobutyric acid (GABA) receptors are involved in the
development of drug dependence. Considering its exclusively extrasynaptic localization …

Association Study of Genetic Polymorphisms in GABRD with Treatment Response and Dose in Methadone Maintenance Treatment

X Xie, J Gu, D Zhuang, X Chen, Y Zhou… - Personalized …, 2021 - Taylor & Francis
Aim: This study determined if gene variants in the GABA receptor delta subunit (GABRD) are
associated with treatment response and dose in methadone maintenance treatment (MMT) …

[HTML][HTML] Copy number variation profile-based genomic typing of premenstrual dysphoric disorder in Chinese

H Xue, Z Wu, X Long, A Ullah, S Chen, WK Mat… - Journal of Genetics and …, 2021 - Elsevier
Premenstrual dysphoric disorder (PMDD) affects nearly 5% of women of reproductive age.
Symptomatic heterogeneity, together with largely unknown genetics, has greatly hindered its …