Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …

The occurrence of DNA double-strand breaks (DSBs) induced by ionizing radiation has
been extensively studied by biochemical or cell imaging techniques. Cell imaging …

Purpose: Understanding the mechanism of radioresistance could help develop strategies to
improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently …

Abstract Myricetin (3, 5, 7, 3′, 4′, 5′-hexahydroxyflavone) is a natural flavonol compound
found in a large variety of plants, including berries, oranges, grapes, herbs, teas, and wine …

Most molecular hallmarks of cellular senescence have been identified in studies of cells
aged in vitro by driving them into replicative or stress-induced senescence. Comparatively …

Recent epidemiology studies highlighted the detrimental health effects of exposure to low
dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown …

At physiological concentrations, reactive oxygen species (ROS), including superoxide
anions and H 2 O 2, are considered as second messengers that play key roles in cellular …