The bacterial protein Hfq: much more than a mere RNA-binding factor

P Sobrero, C Valverde - Critical reviews in microbiology, 2012 - Taylor & Francis
Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq
that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally …

[HTML][HTML] The Escherichia Coli Hfq Protein: An Unattended DNA-Transactions Regulator

GM Cech, A Szalewska-Pałasz, K Kubiak… - Frontiers in molecular …, 2016 - frontiersin.org
The Hfq protein was discovered in Escherichia coli as a host factor for bacteriophage Qβ
RNA replication. Subsequent studies indicated that Hfq is a pleiotropic regulator of bacterial …

Photorhabdus‐nematode symbiosis is dependent on hfq‐mediated regulation of secondary metabolites

NJ Tobias, AK Heinrich, H Eresmann… - Environmental …, 2017 - Wiley Online Library
Photorhabdus luminescens maintains a symbiotic relationship with the nematodes
Heterorhabditis bacteriophora and together they infect and kill insect larvae. To maintain this …

New insight into the structure and function of Hfq C-terminus

E Fortas, F Piccirilli, A Malabirade, V Militello… - Bioscience …, 2015 - portlandpress.com
Accumulating evidence indicates that RNA metabolism components assemble into
supramolecular cellular structures to mediate functional compartmentalization within the …

[HTML][HTML] Revised role for Hfq bacterial regulator on DNA topology

A Malabirade, D Partouche, O El Hamoui, F Turbant… - Scientific Reports, 2018 - nature.com
Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism.
The protein notably regulates translation efficiency and RNA decay in Gram-negative …

Cryo soft X-ray tomography to explore Escherichia coli nucleoid remodeling by Hfq master regulator

A Cossa, S Trépout, F Wien, J Groen, E Le Brun… - Journal of Structural …, 2022 - Elsevier
The bacterial chromosomic DNA is packed within a membrane-less structure, the nucleoid,
due to the association of DNA with proteins called Nucleoid Associated Proteins (NAPs) …

Compaction and condensation of DNA mediated by the C-terminal domain of Hfq

A Malabirade, K Jiang, K Kubiak… - Nucleic Acids …, 2017 - academic.oup.com
Hfq is a bacterial protein that is involved in several aspects of nucleic acids metabolism. It
has been described as one of the nucleoid associated proteins shaping the bacterial …

Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA

JE George, R Basak, I Yadav, CJ Tan, JA van Kan… - Lab on a Chip, 2024 - pubs.rsc.org
Regulation of protein mobility is a fundamental aspect of cellular processes. In this study, we
examined the impact of DNA methylation on the diffusion of nucleoid associated protein Hfq …

Effects of Hfq on the conformation and compaction of DNA

K Jiang, C Zhang, D Guttula, F Liu… - Nucleic acids …, 2015 - academic.oup.com
Hfq is a bacterial pleiotropic regulator that mediates several aspects of nucleic acids
metabolism. The protein notably influences translation and turnover of cellular RNAs …

Interactions between DNA and the Hfq amyloid-like region trigger a viscoelastic response

O El Hamoui, I Yadav, M Radiom, F Wien… - …, 2020 - ACS Publications
Molecular transport of biomolecules plays a pivotal role in the machinery of life. Yet, this role
is poorly understood due the lack of quantitative information. Here, the role and properties of …