Pre-eclampsia

BWJ Mol, CT Roberts, S Thangaratinam, LA Magee… - The Lancet, 2016 - thelancet.com
Summary Pre-eclampsia affects 3–5% of pregnancies and is traditionally diagnosed by the
combined presentation of high blood pressure and proteinuria. New definitions also include …

Children born small for gestational age: differential diagnosis, molecular genetic evaluation, and implications

MJJ Finken, M van der Steen, CCJ Smeets… - Endocrine …, 2018 - academic.oup.com
Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …

Placental exosomes as early biomarker of preeclampsia: potential role of exosomal microRNAs across gestation

C Salomon, D Guanzon… - The Journal of …, 2017 - academic.oup.com
Context There is a need to develop strategies for early prediction of patients who will
develop preeclampsia (PE) to establish preventive strategies to reduce the prevalence and …

Early pregnancy vitamin D status and risk of preeclampsia

H Mirzakhani, AA Litonjua, TF McElrath… - The Journal of …, 2016 - Am Soc Clin Investig
BACKGROUND. Low vitamin D status in pregnancy was proposed as a risk factor of
preeclampsia. METHODS. We assessed the effect of vitamin D supplementation (4,400 vs …

Genetic and non‐genetic risk factors for pre‐eclampsia: umbrella review of systematic reviews and meta‐analyses of observational studies

K Giannakou, E Evangelou… - … in Obstetrics & …, 2018 - Wiley Online Library
Objective To summarize evidence from the literature on genetic and non‐genetic risk factors
associated with pre‐eclampsia (PE), assess the presence of statistical bias in the studies …

Predictive performance of PlGF (placental growth factor) for screening preeclampsia in asymptomatic women: a systematic review and meta-analysis

S Agrawal, S Shinar, AS Cerdeira, C Redman… - …, 2019 - Am Heart Assoc
Preeclampsia is a systemic syndrome that seems to originate from the placenta and is
associated with an imbalance between angiogenic factors in the maternal circulation. One of …

Integrated systems biology approach identifies novel maternal and placental pathways of preeclampsia

NG Than, R Romero, AL Tarca, KA Kekesi… - Frontiers in …, 2018 - frontiersin.org
Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our
understanding of the complex interactions among their respective disease pathways …

The role of endoglin and its soluble form in pathogenesis of preeclampsia

G Margioula-Siarkou, C Margioula-Siarkou… - Molecular and Cellular …, 2022 - Springer
Preeclampsia remains till today a leading cause of maternal and fetal morbidity and
mortality. Pathophysiology of the disease is not yet fully elucidated, though it is evident that it …

The prediction of early preeclampsia: Results from a longitudinal proteomics study

AL Tarca, R Romero, N Benshalom-Tirosh, NG Than… - PloS one, 2019 - journals.plos.org
Objectives To identify maternal plasma protein markers for early preeclampsia (delivery< 34
weeks of gestation) and to determine whether the prediction performance is affected by …

Prediction of pre‐eclampsia: review of reviews

R Townsend, A Khalil, Y Premakumar… - … in Obstetrics & …, 2019 - Wiley Online Library
Objective Primary studies and systematic reviews provide estimates of varying accuracy for
different factors in the prediction of pre‐eclampsia. The aim of this study was to review …