[HTML][HTML] The Impact of Calcium Overload on Cellular Processes: Exploring Calcicoptosis and Its Therapeutic Potential in Cancer
A Gielecińska, M Kciuk, R Kontek - International Journal of Molecular …, 2024 - mdpi.com
The key role of calcium in various physiological and pathological processes includes its
involvement in various forms of regulated cell death (RCD). The concept of 'calcicoptosis' …
involvement in various forms of regulated cell death (RCD). The concept of 'calcicoptosis' …
Metabolic regulation in normal and leukemic stem cells
Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) are crucial for ensuring
hematopoietic homeostasis and driving leukemia progression, respectively. Recent …
hematopoietic homeostasis and driving leukemia progression, respectively. Recent …
Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia
A Khalaf, L de Beauchamp, E Kalkman… - Science Translational …, 2024 - science.org
In chronic myeloid leukemia (CML), the persistence of leukemic stem cells (LSCs) after
treatment with tyrosine kinase inhibitors (TKIs), such as imatinib, can lead to disease …
treatment with tyrosine kinase inhibitors (TKIs), such as imatinib, can lead to disease …
[HTML][HTML] Unlocking the Heterogeneity in Acute Leukaemia: Dissection of Clonal Architecture and Metabolic Properties for Clinical Interventions
MM Capelletti, O Montini, E Ruini, S Tettamanti… - International Journal of …, 2024 - mdpi.com
Genetic studies of haematological cancers have pointed out the heterogeneity of leukaemia
in its different subpopulations, with distinct mutations and characteristics, impacting the …
in its different subpopulations, with distinct mutations and characteristics, impacting the …
STAT3 modulates mitochondrial function and plays a critical role in the survival of leukemic stem cells
KB Gil, J Borg, R Moreira Pereira, A Inguva-Sheth… - bioRxiv, 2024 - biorxiv.org
Signal transducer and activator of transcription 3 (STAT3) is a well-described transcription
factor that mediates oxidative phosphorylation and glutamine uptake in bulk acute myeloid …
factor that mediates oxidative phosphorylation and glutamine uptake in bulk acute myeloid …
Metabolic dependencies of acute myeloid leukemia stem cells
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven
by an immature population of AML cells termed leukemia stem cells (LSCs) that are …
by an immature population of AML cells termed leukemia stem cells (LSCs) that are …
Berberine is a novel mitochondrial calcium uniporter (MCU) inhibitor that disrupts MCU-EMRE assembly
H Zhao, S Chen, N Cao, W Wu, G Liu, J Gao, J Chen… - bioRxiv, 2024 - biorxiv.org
The mitochondrial calcium uniporter (MCU) complex, localized in the inner mitochondrial
membrane, plays a crucial role in regulating mitochondrial Ca2+ influx, thereby impacting …
membrane, plays a crucial role in regulating mitochondrial Ca2+ influx, thereby impacting …
Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.
N Balasundaram, A Venkatraman, Y Augustin… - bioRxiv, 2024 - biorxiv.org
Acute myeloid leukemia (AML) remains a difficult disease to cure despite recent advances.
Off-target side effects of therapy, especially prolonged cytopenia, lead to significant …
Off-target side effects of therapy, especially prolonged cytopenia, lead to significant …