Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium)-induced hepatotoxicity–A review

K Renu, R Chakraborty, H Myakala, R Koti… - Chemosphere, 2021 - Elsevier
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much
heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious …

Protective effect of curcumin against heavy metals-induced liver damage

WR García-Niño, J Pedraza-Chaverrí - Food and chemical toxicology, 2014 - Elsevier
Occupational or environmental exposures to heavy metals produce several adverse health
effects. The common mechanism determining their toxicity and carcinogenicity is the …

Protective effect of hesperidin on sodium arsenite-induced nephrotoxicity and hepatotoxicity in rats

E Turk, FM Kandemir, S Yildirim, C Caglayan… - Biological trace element …, 2019 - Springer
The present study was conducted to investigate the protective effects of hesperidin (HSP)
against sodium arsenite (SA)-induced nephrotoxicity and hepatotoxicity in rats. Thirty-five …

The role of inflammation in cadmium nephrotoxicity: NF-κB comes into view

EHM Hassanein, WR Mohamed, OS Ahmed… - Life Sciences, 2022 - Elsevier
Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

An appraisal on molecular and biochemical signalling cascades during arsenic-induced hepatotoxicity

K Renu, A Saravanan, A Elangovan, S Ramesh… - Life sciences, 2020 - Elsevier
Arsenic is a ubiquitous metalloid compound commonly found in the environment, and it is
usually found in combination with sulphur and metals. Arsenic is considered as a …

Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis

MA Dkhil, AE Abdel Moneim, AA Bauomy… - Molecular biology …, 2020 - Springer
Arsenic is a potent and toxic heavy metal found in the environment that causes health
problems, including liver disease, in humans and animals. Chlorogenic acid (CA) is the most …

Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses

MF El-Khadragy, WA Al-Megrin, S Alomar… - Chemico-biological …, 2021 - Elsevier
Arsenic, a major environmental pollutant of global concern, is well-known for its reproductive
toxicity. In this study, the protective potential of chlorogenic acid (CGA), a caffeoylquinic acid …

Hepatoprotective and anti-hyperglycemic effects of ferulic acid in arsenic-exposed mice

M Daryagasht, M Moosavi, L Khorsandi… - Food and Chemical …, 2023 - Elsevier
Arsenic is a toxic metalloid that increases the risk of hepatotoxicity and hyperglycemia. The
objective of the present study was to assess the effect of ferulic acid (FA) in mitigating …

[HTML][HTML] Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis

DM Metwally, RA Alajmi, MF El-Khadragy… - Journal of functional …, 2020 - Elsevier
Arsenic is a potent neurotoxic xenobiotic found in drinking water, and food. Chlorogenic acid
(CGA), an abundant polyphenol in coffee, potentially has a wide range of therapeutic …

Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats

V Bodaghi-Namileh, MR Sepand, A Omidi… - Environmental …, 2018 - Elsevier
Industrial and agricultural developments in recent years have resulted in the excessive
discharge of arsenic into the environment, making arsenic toxicity a major worldwide …