The development of thrombotic disorders in humans is one of the most common causes of
morbidity and mortality in the Western world. Thrombotic disease can be classified in broad …

Background In the context of a comprehensive population strategy to reduce tobacco use,
encourage healthy food choices, and increase physical activity for the whole population, the …

Since the first Joint European Societies (European Society of Cardiology, European
Atherosclerosis Society and European Society of Hypertension) Task Force …

Interleukin-6 (IL-6) synthesized in response to diverse stimuli may play an important role in
bridging the inflammatory and atherosclerotic processes. The acute-phase response after …

Background—It is pathophysiologically conceivable that genetic variations in coagulation
and fibrinolytic proteins are associated with the risk of myocardial infarction. Methods and …

Recently, we have shown that two alleles of the glycoprotein (GP) Ia gene, designated C807
and T807, are associated with low or high platelet GPIa-IIa density and consequently with …

Background Blood concentrations of fibrinogen have been associated with coronary heart
disease risk in epidemiological studies, but it is uncertain whether this association is causal …

Fibrinogen plays a key role in platelet aggregation, the final step of the coagulation cascade,
ie the formation of fibrin, and it is a major determinant of plasma viscosity and erythrocyte …

The pathogenesis of arterial thrombotic disease involves multiple genetic and environmental
factors related to atherosclerosis and thrombosis. Acute thrombosis at the site of a ruptured …

Arterial and venous thromboses, with their clinical manifestations such as stroke, myocardial
infarction (MI), or pulmonary embolism, are the major causes of death in developed …