Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90%
of all forms of oral cancer worldwide. Although great efforts have been made in the past …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in
human cancers,,,–. However, the role and the molecular mechanisms by which FAT1 …

Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with
cancer stem cells (CSC) to maintain stemness. We recently identified cluster of …

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in
migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT …

Hypoxia has been shown to increase the aggressiveness and severity of tumor progression.
Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling …

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting
of cancer. Accumulating evidence suggests that a fraction of cells within a tumor termed …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Epithelial mesenchymal transition (EMT) is a complex process through which epithelial (E)
cells lose their adherens junctions, transform into mesenchymal (M) cells and attain motility …

Metastasis is the leading cause of mortality among cancer patients. Dissemination enabled
by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been …