Until recently, understanding the regulatory behavior of cells has been pursued through
independent analysis of the transcriptome or the proteome. Based on the central dogma, it …

The candidate gene approach has been a pioneer in the field of genetic epidemiology,
identifying risk alleles and their association with clinical traits. With the advent of rapidly …

Transcriptional cascades that operate over the course of lineage development are
fundamental mechanisms that control cellular differentiation. In the developing central …

Recent studies have identified stem cells in brain cancer. However, their relationship to
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …

Neuronal activity orchestrates the proper development of the neuronal circuitry by regulating
both transcriptional and post‐transcriptional gene expression programmes. How these …

Finding where transcription factors (TFs) bind to the DNA is of key importance to decipher
gene regulation at a transcriptional level. Classically, computational prediction of TF binding …

Regulation of gene expression influences almost all biological processes in an organism;
sequence-specific DNA-binding transcription factors are critical to this control. For most …

The application of primary human hepatocytes following isolation from human tissue is well
accepted to be compromised by the process of dedifferentiation. This phenomenon reduces …

Basal-like breast cancer (BLBC) is an aggressive disease that lacks a clinically approved
targeted therapy. Traditional chemotherapy is effective in BLBC, but it spares the cancer …

Background Interferon γ (IFNγ) is considered a seminal cytokine in the pathogenesis of giant
cell arteritis (GCA), but its functional role has not been investigated. We explored changes in …