By inhibiting prostaglandin synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) cause
mucosal damage, ulceration and ulcer complication throughout the gastrointestinal tract …

Objectives: To provide an updated document assessing the global, NSAID-specific, and time
dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality …

In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory,
and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non …

Meloxicam is a new nonsteroidal anti-inflammatory drug (NSAID) developed for the
treatment of rheumatoid arthritis and osteoarthritis. It has greater in vitro and in vivo inhibitory …

Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs.
The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive …

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 45, presents
comprehensive reviews of drug substances and additional materials, with critical review …

In addition to housekeeping cyclooxygenase (COX)-1, which is constitutively expressed in
many body cells, an inducible COX-2 has been described and cloned. Induction or presence …

The discovery of at least 2 cyclo-oxygenase (COX) isoenzymes, referred to as COX-1 and
COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This …

Publisher Summary This chapter focuses on selective inhibitors of cyclooxygenase-2 (COX-
2). Two distinct COX enzymes were recently identified (i) a constitutive form (COX-1) present …

Background and Aim Meloxicam (MX) is a potent hydrophobic non-steroidal anti-
inflammatory drug used to reduce inflammation and pain. However, its oral dosage form can …