Background Xpert MTB/RIF Ultra (Xpert Ultra) and Xpert MTB/RIF are World Health
Organization (WHO)‐recommended rapid nucleic acid amplification tests (NAATs) widely …

Introduction: HIV-associated cryptococcal, TB and pneumococcal meningitis are the leading
causes of adult meningitis in sub-Saharan Africa (SSA). We performed a systematic review …

Introduction Tuberculous meningitis accounts for 1–5% of tuberculosis cases. Diagnostic
delay contributes to poor outcomes. We evaluated the performance of the new Xpert …

Background There is substantial variation in the reported treatment outcomes for adult
tuberculous meningitis (TBM). Data on survival and neurological disability by continent and …

Background Central nervous system (CNS) infections remain a major public health problem
in Sub-Saharan Africa, causing 15%–25% of AIDS-related deaths. With widespread …

Diagnosis of tuberculous meningitis (TBM) remains challenging due to a paucity of high-
performance diagnostics. Even those that have reasonable sensitivity are not adequate to …

Background Fungal infections are common in HIV-infected individuals and significantly
contribute to mortality. However, a substantial number of cases are undiagnosed before …

The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary
molecular biology technologies have allowed for recent improvements in our understanding …

Tuberculous meningitis (TBM) is a commonly encountered central nervous system infection.
Characteristic clinical, imaging and cerebrospinal fluid parameters help clinicians to make a …

Objective The GeneXpert MTB/RIF assay (Xpert) is a diagnostic tool that has been shown to
significantly improve the accuracy of tuberculosis (TB) detection in clinical settings, with …