The LC8 family members of dynein light chains (DYNLL1 and DYNLL2 in vertebrates) are
highly conserved ubiquitous eukaryotic homodimer proteins that interact, besides dynein …

Intestinal barrier function and microbiota are integrally related and play critical roles in
maintenance of host physiology. Sex is a key biologic variable for several disorders. Our aim …

The highly conserved DYNLL1 (LC8) protein was originally discovered as a light chain of
the dynein motor complex, but is increasingly emerging as a sequence-specific regulator of …

Background FSGS caused by mutations in INF2 is characterized by a podocytopathy with
mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a …

Immunological synapse (IS) formation between a T cell and an antigen-presenting cell is
accompanied by the reorientation of the T cell centrosome toward the interface. This …

Cytoplasmic dynein and dynactin participate in retrograde transport of organelles,
checkpoint signaling and cell division. The principal subunits that mediate this interaction …

Cytoplasmic dynein is a large multisubunit complex involved in retrograde transport and the
positioning of various organelles. Dynein light chain (LC) subunits are conserved across …

ABSTRACT GPCR kinase 2–interacting protein‐1 (GIT1) is a scaffold protein that plays an
important role in cell adaptation, proliferation, migration, and differentiation; however, the …

Dynein light chain 1 (LC8), a highly conserved protein, is known to bind to a variety of
different polypeptides. It functions as a dimer, which is inactivated through phosphorylation …

LC8 dynein light chain (DYNLL) is a highly conserved eukaryotic hub protein with dozens of
binding partners and various functions beyond being a subunit of dynein and myosin Va …