The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …

At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …

CK2 is a highly conserved tetrameric serine/threonine kinase present in all eukaryotic
organisms. It is constitutively active, and appears to be regulated by level of expression and …

The Nuclear Factor-κB (NF-κB) signaling pathway has been linked to several pathologic
processes in the myocardium including cardiomyocyte proinflammatory cytokine release …

NF-κB is a major gene regulator in immune responses, and ribosomal protein S3 (RPS3) is
an NF-κB subunit that directs specific gene transcription. However, it is unknown how …

Objective: To evaluate the expressions of nuclear factor κB (NF-κB p65), inducible nitric
oxide synthase enzyme (iNOS), and vascular endothelial growth factor (VEGF) in relation to …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists,
and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by …

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

Age-associated differences in estrogen levels critically modify the cutaneous wound healing
response. Using a microarray-based approach, we profiled changes in gene expression …