NF-κB activation as a pathological mechanism of septic shock and inflammation
SF Liu, AB Malik - … Journal of Physiology-Lung Cellular and …, 2006 - journals.physiology.org
The pathophysiology of sepsis and septic shock involves complex cytokine and
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …
inflammatory mediator networks. NF-κB activation is a central event leading to the activation …
Addiction to protein kinase CK2: a common denominator of diverse cancer cells?
At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …
Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-κB signaling: Linking development and cancer
I Dominguez, GE Sonenshein, DC Seldin - Cellular and Molecular Life …, 2009 - Springer
CK2 is a highly conserved tetrameric serine/threonine kinase present in all eukaryotic
organisms. It is constitutively active, and appears to be regulated by level of expression and …
organisms. It is constitutively active, and appears to be regulated by level of expression and …
Regulating the regulator: NF-κB signaling in heart
G Hall, JD Hasday, TB Rogers - Journal of molecular and cellular …, 2006 - Elsevier
The Nuclear Factor-κB (NF-κB) signaling pathway has been linked to several pathologic
processes in the myocardium including cardiomyocyte proinflammatory cytokine release …
processes in the myocardium including cardiomyocyte proinflammatory cytokine release …
IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7
F Wan, A Weaver, X Gao, M Bern, PR Hardwidge… - Nature …, 2011 - nature.com
NF-κB is a major gene regulator in immune responses, and ribosomal protein S3 (RPS3) is
an NF-κB subunit that directs specific gene transcription. However, it is unknown how …
an NF-κB subunit that directs specific gene transcription. However, it is unknown how …
Expressions of nuclear factor κB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations …
J Zhang, B Peng, X Chen - Clinical Cancer Research, 2005 - AACR
Objective: To evaluate the expressions of nuclear factor κB (NF-κB p65), inducible nitric
oxide synthase enzyme (iNOS), and vascular endothelial growth factor (VEGF) in relation to …
oxide synthase enzyme (iNOS), and vascular endothelial growth factor (VEGF) in relation to …
Therapeutic targeting of CK2 in acute and chronic leukemias
F Buontempo, JA McCubrey, E Orsini, M Ruzzene… - Leukemia, 2018 - nature.com
CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …
[HTML][HTML] CK2α/CSNK2A1 phosphorylates SIRT6 and is involved in the progression of breast carcinoma and predicts shorter survival of diagnosed patients
Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists,
and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by …
and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by …
Kinase CK2 inhibition: an update
Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …
Macrophage migration inhibitory factor: a central regulator of wound healing
MJ Hardman, A Waite, L Zeef, M Burow… - The American journal of …, 2005 - Elsevier
Age-associated differences in estrogen levels critically modify the cutaneous wound healing
response. Using a microarray-based approach, we profiled changes in gene expression …
response. Using a microarray-based approach, we profiled changes in gene expression …