Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
The UCSC genome browser database: 2024 update
Abstract The UCSC Genome Browser (https://genome. ucsc. edu) is a web-based genomic
visualization and analysis tool that serves data to over 7,000 distinct users per day …
visualization and analysis tool that serves data to over 7,000 distinct users per day …
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
Genome annotation: From human genetics to biodiversity genomics
R Guigó - Cell Genomics, 2023 - cell.com
Within the next decade, the genomes of 1.8 million eukaryotic species will be sequenced.
Identifying genes in these sequences is essential to understand the biology of the species …
Identifying genes in these sequences is essential to understand the biology of the species …
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo
ME Oomen, ME Torres-Padilla - EMBO reports, 2024 - embopress.org
Remnants of transposable elements (TEs) are widely expressed throughout mammalian
embryo development. Originally infesting our genomes as selfish elements and acting as a …
embryo development. Originally infesting our genomes as selfish elements and acting as a …
Evolution of a novel adrenal cell type that promotes parental care
N Niepoth, JR Merritt, M Uminski, E Lei, VS Esquibies… - Nature, 2024 - nature.com
Cell types with specialized functions fundamentally regulate animal behaviour, and yet the
genetic mechanisms that underlie the emergence of novel cell types and their …
genetic mechanisms that underlie the emergence of novel cell types and their …
GET_PANGENES: calling pangenes from plant genome alignments confirms presence-absence variation
B Contreras-Moreira, S Saraf, G Naamati, AM Casas… - Genome Biology, 2023 - Springer
Crop pangenomes made from individual cultivar assemblies promise easy access to
conserved genes, but genome content variability and inconsistent identifiers hamper their …
conserved genes, but genome content variability and inconsistent identifiers hamper their …
The evolution history of an allotetraploid mangrove tree analysed with a new tool Allo4D
Y Wang, Y Li, W Wu, S Shao, Q Fang… - Plant Biotechnology …, 2024 - Wiley Online Library
Mangrove species are broadly classified as true mangroves and mangrove associates. The
latter are amphibious plants that can survive in the intertidal zone and reproduce naturally in …
latter are amphibious plants that can survive in the intertidal zone and reproduce naturally in …
Accurate microRNA annotation of animal genomes using trained covariance models of curated microRNA complements in MirMachine
SU Umu, VM Paynter, H Trondsen, T Buschmann… - Cell Genomics, 2023 - cell.com
The annotation of microRNAs depends on the availability of transcriptomics data and expert
knowledge. This has led to a gap between the availability of novel genomes and high …
knowledge. This has led to a gap between the availability of novel genomes and high …
ToxCodAn-Genome: an automated pipeline for toxin-gene annotation in genome assembly of venomous lineages
Background The rapid development of sequencing technologies resulted in a wide
expansion of genomics studies using venomous lineages. This facilitated research focusing …
expansion of genomics studies using venomous lineages. This facilitated research focusing …