Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

A Rodríguez, S Ezquerro… - American Journal …, 2015 - journals.physiology.org
Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

[HTML][HTML] Molecular mechanisms governing aquaporin relocalisation

A Markou, L Unger, M Abir-Awan, A Saadallah… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The aquaporins (AQPs) form a family of integral membrane proteins that facilitate the
movement of water across biological membrane by osmosis, as well as facilitating the …

[HTML][HTML] Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

S Bestetti, M Galli, I Sorrentino, P Pinton, A Rimessi… - Redox Biology, 2020 - Elsevier
Abstract Hydrogen peroxide (H 2 O 2) is an essential second intracellular messenger. To
reach its targets in the cytosol, H 2 O 2 must cross a membrane, a feat that requires …

ER stress and inflammation crosstalk in obesity

A Ajoolabady, C Lebeaupin, NN Wu… - Medicinal research …, 2023 - Wiley Online Library
The endoplasmic reticulum (ER) governs the proper folding of polypeptides and proteins
through various chaperones and enzymes residing within the ER organelle. Perturbation in …

Evolution and functional diversity of aquaporins

RN Finn, J Cerdà - The Biological Bulletin, 2015 - journals.uchicago.edu
In this review, we provide a brief synopsis of the evolution and functional diversity of the
aquaporin gene superfamily in prokaryotic and eukaryotic organisms. Based upon the latest …

Aquaporins in cancer biology

CS Moon, D Moon, SK Kang - Frontiers in oncology, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of transmembrane water channel proteins, which were
initially characterized as a novel protein family that plays a vital role in transcellular and …

Beyond water homeostasis: Diverse functional roles of mammalian aquaporins

P Kitchen, RE Day, MM Salman, MT Conner… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Background Aquaporin (AQP) water channels are best known as passive transporters of
water that are vital for water homeostasis. Scope of review AQP knockout studies in whole …

miR-27a-3p protects against blood–brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11

T Xi, F Jin, Y Zhu, J Wang, L Tang, Y Wang… - Journal of Biological …, 2018 - ASBMB
Previous studies have reported that miR-27a-3p is down-regulated in the serum of patients
with intracerebral hemorrhage (ICH), but the implication of miR-27a-3p down-regulation in …

Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease

K Wagner, L Unger, MM Salman, P Kitchen… - International Journal of …, 2022 - mdpi.com
The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the
bidirectional transport of water across biological membranes in response to osmotic …

Mechanisms of aquaporin-facilitated cancer invasion and metastasis

ML De Ieso, AJ Yool - Frontiers in chemistry, 2018 - frontiersin.org
Cancer is a leading cause of death worldwide, and its incidence is rising with numbers
expected to increase 70% in the next two decades. The fact that current mainline treatments …