Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Neutrophils are produced in the bone marrow from stem cells that proliferate and
differentiate to mature neutrophils fully equipped with an armory of granules. These contain …

A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases
(PM) in the course of their disease. PMs are associated with a poor quality of life, significant …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix
developed by cells in culture. They provide a structural link between the actin cytoskeleton …

Abstract Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the
occurrence of bilateral vestibular schwannomas and other central nervous system tumors …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

The hiatus between oocyte and embryonic gene transcription dictates a role for stored
maternal factors in early mammalian development. Encoded by maternal-effect genes, these …

The ezrin/radixin/moesin (ERM) proteins are involved in actin filament/plasma membrane
interaction that is regulated by Rho. We examined whether ERM proteins are directly …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …