Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …

The need for new antifungal agents is undeniable. Current therapeutic choices for the
treatment of invasive fungal infections are limited to three classes of drugs. Most used …

Invasive, life-threatening fungal infections are an important cause of morbidity and mortality,
particularly for patients with compromised immune function. The number of therapeutic …

Recent investigations have yielded both profound insights into the mechanisms required by
pathogenic fungi for virulence within the human host, as well as novel potential targets for …

Fungal organisms are ubiquitous in nature, and progress of modern medicine is creating an
expanding number of severely compromised patients susceptible to a variety of …

Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus cause life-
threatening candidiasis, cryptococcosis, and aspergillosis, resulting in several hundred …

Candida auris is an emerging fatal fungal infection that has resulted in several outbreaks in
hospitals and care facilities. Current treatment options are limited by the development of …

Many infectious diseases disproportionately affect people in the developing world.
Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the …

Fungal pathogens pose serious threats to human, plant, and ecosystem health. Improved
diagnostics and antifungal strategies are therefore urgently required. Here, we review recent …

Series of semi-synthetic polyene macrolide antibiotics (PMAs) that were prepared by
chemical modification in original research by the authors are reviewed. Chemical …