Recent advances in optical mapping have allowed the construction of improved genome
assemblies with greater contiguity. Optical mapping also enables genome comparison and …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Background Identification of pathogens is crucial to efficiently treat and prevent bacterial
infections. However, existing diagnostic techniques are slow or have a too low resolution for …

Motivation Optical genome mapping (OGM) is a technique that extracts partial genomic
information from optically imaged and linearized DNA fragments containing fluorescently …

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the
major reason of cell death. Here, we use an assay based on fluorescence imaging of single …

A variety of pathogenic bacteria can infect humans, and rapid species identification is crucial
for the correct treatment. However, the identification process can often be time-consuming …

Quantification of the DNA damage induced by chemotherapy in patient cells may aid in
personalization of the dose used. However, assays to evaluate individual patient response …

Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of
single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes …

DNA optical mapping in nanochannels allows studying intact molecules and analyzing their
long-range structure at the single-molecule level. Recent efforts have demonstrated that …