Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels
Single-cell multiomic understanding of HIV-1 reservoir at ep... : Current Opinion in HIV and
AIDS Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and …
AIDS Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and …
Tiled-ClickSeq for targeted sequencing of complete coronavirus genomes with simultaneous capture of RNA recombination and minority variants
E Jaworski, RM Langsjoen, B Mitchell, B Judy… - Elife, 2021 - elifesciences.org
High-throughput genomics of SARS-CoV-2 is essential to characterize virus evolution and to
identify adaptations that affect pathogenicity or transmission. While single-nucleotide …
identify adaptations that affect pathogenicity or transmission. While single-nucleotide …
Activation of HIV-1 proviruses increases downstream chromatin accessibility
It is unclear how the activation of HIV-1 transcription affects chromatin structure. We
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …
interrogated chromatin organization both genome-wide and nearby HIV-1 integration sites …
[PDF][PDF] Elevated HIV viral load is associated with higher recombination rate in vivo
HIV's exceptionally high recombination rate drives its intrahost diversification, enabling
immune escape and multidrug resistance within people living with HIV. While we know that …
immune escape and multidrug resistance within people living with HIV. While we know that …
ViReMa: a virus recombination mapper of next-generation sequencing data characterizes diverse recombinant viral nucleic acids
Background Genetic recombination is a tremendous source of intrahost diversity in viruses
and is critical for their ability to rapidly adapt to new environments or fitness challenges …
and is critical for their ability to rapidly adapt to new environments or fitness challenges …
HIV-PULSE: a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization
L Lambrechts, N Bonine, R Verstraeten… - Nucleic Acids …, 2023 - academic.oup.com
A deep understanding of the composition of the HIV-1 reservoir is necessary for the
development of targeted therapies and the evaluation of curative efforts. However, current …
development of targeted therapies and the evaluation of curative efforts. However, current …
Covariation of viral recombination with single nucleotide variants during virus evolution revealed by CoVaMa
Adaptation of viruses to their environments occurs through the acquisition of both novel
single-nucleotide variants (SNV) and recombination events including insertions, deletions …
single-nucleotide variants (SNV) and recombination events including insertions, deletions …
Selective ablation of 3′ RNA ends and processive RTs facilitate direct cDNA sequencing of full-length host cell and viral transcripts
CM Gallardo, AVT Nguyen, AL Routh… - Nucleic acids …, 2022 - academic.oup.com
Alternative splicing (AS) is necessary for viral proliferation in host cells and a critical
regulatory component of viral gene expression. Conventional RNA-seq approaches provide …
regulatory component of viral gene expression. Conventional RNA-seq approaches provide …
Multiplexed approaches to investigate cellular mechanisms underlying HIV-1 transcriptional competence and viral replication
R Shah - 2021 - search.proquest.com
Human immunodeficiency virus type 1 (HIV-1) remains a global public health burden with
approximately 38 million individuals living with the disease in 2019 and 1.7 million new …
approximately 38 million individuals living with the disease in 2019 and 1.7 million new …