Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

Development of multicellular organisms requires the differential usage of our genetic
information to change one cell fate into another. This process drives the appearance of …

In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased
deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression …

Human hematopoietic stem cells (HSCs), which arise from aorta-gonad-mesonephros
(AGM), are widely used to treat blood diseases and cancers. However, a technique for their …

Abstract Knowledge of human fetal blood development and how it differs from adult blood is
highly relevant to our understanding of congenital blood and immune disorders and …

As a transcription factor in the RUNT domain core-binding factor family, RUNX1 is crucial in
multiple stages of hematopoiesis, and its mutation can cause familial platelet disorder with a …

The Chd8 gene encodes a member of the chromodomain helicase DNA-binding (CHD)
family of SNF2H-like adenosine triphosphate (ATP)-dependent chromatin remodeler, the …

Background: Regulation of gene expression is critical for stem cell differentiation, tissue
development, and human health maintenance. Recently, epigenetic modifications of histone …

Embryoid cells and induced pluripotent stem cells (iPSCs) are pluripotent stem cells (PSCs).
They retain differentiation and self-renewal potential. However, the differentiation potential of …

Chromatin, a protein–DNA complex, is a dynamic structure that stores genetic information
within the nucleus and responds to molecular/cellular changes in its structure, providing …