SARS-CoV-2 infection (COVID-19) is currently a tremendous global health problem. COVID-
19 causes considerable damage to a wide range of vital organs most prominently the …

This review describes precisely the consequence of TGFβ1 prevalence in the organism, and
its significant influence on physiological and pathophysiological processes. Organ and …

The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling
pathway, activated by more than 50 cytokines or growth factors, plays critical roles in a wide …

T cell–mediated fulminant hepatitis is a life-threatening event for which the underlying
mechanism is not fully understood. Injection of concanavalin A (Con A) into mice …

Background & Aims: Recent evidence suggests that toll-like receptors (TLRs) recognize
certain viruses. We reported that hepatitis C virus (HCV) core and nonstructural 3 (NS3) …

Hepatitis C virus (HCV) is a leading cause of chronic liver disease that can progress to
cirrhosis and/or hepatocellular carcinoma. Intrahepatic inflammation and liver cell injury are …

T-cell immunoregulatory cytokines influence the persistence of hepatitis C virus (HCV)
chronic infection and the extent of liver damage. Th1 cytokines positively correlate with …

We have previously shown that IFN-γ/STAT1 plays an essential role in concanavalin A
(ConA)-induced T cell hepatitis via activation of apoptotic signaling pathways. Here we …

Background & Aims: Hepatic lymphocytes are composed mainly of natural killer (NK) cells
and NKT cells, which play key roles in innate immune responses against pathogens and …

Due to shared risk factors for transmission, coinfection with human immunodeficiency virus
(HIV) and hepatitis C virus (HCV) is a very common event. The prevalence of HCV infection …