Astrocytes are the most abundant cell type within the central nervous system. They play
essential roles in maintaining normal brain function, as they are a critical structural and …

The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …

This article introduces the special issue on “Blood–Brain Barrier and Epilepsy.” We review
briefly current understanding of the structure and function of the blood–brain barrier (BBB) …

Astrocyte dysfunction has previously been linked to multiple neurodegenerative disorders
including Parkinson's disease (PD). Among their many roles, astrocytes are mediators of the …

OBJECTIVE Preclinical studies have suggested that thrombospondin-2 (TSP2) is implicated
in liver fibrosis. However, the clinical relevance of TSP2 in nonalcoholic fatty liver disease …

Angiogenesis is vital to developmental, regenerative and repair processes. It is normally
regulated by a balanced production of pro-and anti-angiogenic factors. Alterations in this …

Diseases that affect the Central Nervous System (CNS) are one of the most exciting
challenges of recent years, as they are ubiquitous and affect all ages. Although these …

Stroke is a complex disease caused by genetic and environmental factors, and its etiological
mechanism has not been fully clarified yet, which brings great challenges to its effective …

Blood–brain barrier (BBB) dysfunction emerges as one of the mechanisms underlying the
induction of seizures and epileptogenesis. There is growing evidence that seizures also …

Intracranial implants elicit neurodegeneration via the foreign body response (FBR) that
includes BBB leakage, macrophage/microglia accumulation, and reactive astrogliosis, in …