Mammalian excitatory synapses express diverse types of synaptic plasticity. A major
challenge in neuroscience is to understand how a neuron utilizes different types of plasticity …

Promyelocytic leukemia protein (PML) was originally identified as a fusion partner of retinoic
acid receptor alpha in acute promyelocytic leukemia patients with the (15; 17) chromosomal …

Spatial genome organization and its effect on transcription remains a fundamental question.
We applied an advanced chromatin interaction analysis by paired-end tag sequencing …

Herpes simplex virus (HSV) establishes latent infection in long‐lived neurons. During initial
infection, neurons are exposed to multiple inflammatory cytokines but the effects of immune …

Activity-dependent alteration of the transcriptional program is central for shaping neuronal
connectivity. Constitutively expressed transcription factors orchestrate the initial response to …

The current view of neuroplasticity depicts the changes in the strength and number of
synaptic connections as the main physical substrate for behavioral adaptation to new …

Emerging therapies for Angelman syndrome, a severe neurodevelopmental disorder, are
focused on restoring UBE3A gene expression in the brain. Further therapeutic opportunities …

Spatial chromatin organization is crucial for transcriptional regulation and might be
particularly important in neurons since they dramatically change their transcriptome in …

A single episode of pilocarpine-induced status epilepticus can trigger the development of
spontaneous recurrent seizures in a rodent model for epilepsy. The initial seizure-induced …

The ability to regulate chromatin organization is particularly important in neurons, which
dynamically respond to external stimuli. Accumulating evidence shows that lncRNAs play …