It has been known for decades that DNA is extremely flexible and polymorphic, but our
knowledge of its accessible conformational space remains limited. Structural data, primarily …

RNA folding is a remarkably complex problem that involves ion-mediated electrostatic
interaction, conformational entropy, base pairing and stacking, and noncanonical …

Single-molecule measurements of biomolecules can provide information about the
molecular interactions and kinetics that are hidden in ensemble measurements. However …

Nucleic acid hairpins provide a powerful model system for probing the formation of
secondary structure. We report a systematic study of the kinetics and thermodynamics of the …

We have investigated the structure and unfolding kinetics of the human telomeric
intramolecular G quadruplex by using single-molecule fluorescence resonance energy …

Multivalent nanoparticles have tremendous potential in the diagnosis and treatment of
human disease.[1] Their multivalency allows simultaneous conjugation of targeting ligands …

Sequence analogs of human telomeric DNA such as d [AGGG (TTAGGG) 3](Tel22) fold into
monomeric quadruplex structures in the presence of a suitable cation. To investigate the …

Dissolution of cellulose having different viscosity-average molecular weight (M η) in 7 wt%
NaOH/12 wt% urea aqueous solution at temperature from 60 to− 12.6° C was investigated …

Determining the sequence-recognition properties of DNA-binding proteins and small
molecules remains a major challenge. To address this need, we have developed a high …

Large noncoding RNAs fold into their biologically functional structures via compact yet
disordered intermediates, which couple the stable secondary structure of the RNA with the …