Despite the extensive discovery of trait-and disease-associated common variants, much of
the genetic contribution to complex traits remains unexplained. Rare variants can explain …

During the past decade, genome-wide association studies (GWAS) have been used to
successfully identify tens of thousands of genetic variants associated with complex traits and …

Significance testing was developed as an objective method for summarizing statistical
evidence for a hypothesis. It has been widely adopted in genetic studies, including genome …

Meta-analysis of whole genome sequencing/whole exome sequencing (WGS/WES) studies
provides an attractive solution to the problem of collecting large sample sizes for discovering …

Motivation: Imputation using external reference panels (eg 1000 Genomes) is a widely used
approach for increasing power in genome-wide association studies and meta-analysis …

The majority of reported complex disease associations for common genetic variants have
been identified through meta-analysis, a powerful approach that enables the use of large …

This tutorial is a learning resource that outlines the basic process and provides specific
software tools for implementing a complete genome‐wide association analysis. Approaches …

The exact aetiology of Crohn's disease is unknown, though it is clear from early
epidemiological studies that a combination of genetic and environmental risk factors …

Malocclusions affect individuals worldwide, resulting in compromised function and esthetics.
Understanding the etiological factors contributing to the variation in dentofacial morphology …

Integrating association evidence across multiple traits can improve the power of gene
discovery and reveal pleiotropy. Most multi-trait analysis methods focus on individual …