Applications of single-cell sequencing in cancer research: progress and perspectives

Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

[HTML][HTML] New insights from the single-cell level: tumor associated macrophages heterogeneity and personalized therapy

X Wang, Y Xu, Q Sun, X Zhou, W Ma, JB Wu… - Biomedicine & …, 2022 - Elsevier
Tumor-associated macrophages (TAMs) are important immune cells in the tumor
microenvironment, and their invasion in tumors is closely related to poor prognosis …

B2M overexpression correlates with malignancy and immune signatures in human gliomas

H Zhang, B Cui, Y Zhou, X Wang, W Wu, Z Wang… - Scientific Reports, 2021 - nature.com
Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is
finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin …

Immune infiltrating cells-derived risk signature based on large-scale analysis defines immune landscape and predicts immunotherapy responses in glioma tumor …

N Zhang, H Zhang, Z Wang, Z Dai, X Zhang… - Frontiers in …, 2021 - frontiersin.org
The glioma tumor microenvironment (TME), composed of several noncancerous cells and
biomolecules is known for its complexity of cancer-immune system interaction. Given that …

Protein disulfide-isomerase A3 is a robust prognostic biomarker for cancers and predicts the immunotherapy response effectively

Z Tu, Q Ouyang, X Long, L Wu, J Li, X Zhu… - Frontiers in …, 2022 - frontiersin.org
Background Protein disulfide isomerase A3 (PDIA3) is a member of the protein disulfide
isomerase (PDI) family that participates in protein folding through its protein disulfide …

Characterization of an endoplasmic reticulum stress‐related signature to evaluate immune features and predict prognosis in glioma

Q Zhang, G Guan, P Cheng, W Cheng… - Journal of cellular …, 2021 - Wiley Online Library
Endoplasmic reticulum (ER) stress has considerable impact on cell growth, proliferation,
metastasis, invasion, angiogenesis and chemoradiotherapy resistance in various cancers …

Novel immune infiltrating cell signature based on cell pair algorithm is a prognostic marker in cancer

H Zhang, Z Wang, Z Dai, W Wu, H Cao, S Li… - Frontiers in …, 2021 - frontiersin.org
Tumor-infiltrating immune cells (TIICs) have become an important source of markers for
predicting the clinical outcomes of cancer patients. However, measurements of cellular …

The predictive value of monocytes in immune microenvironment and prognosis of glioma patients based on machine learning

N Zhang, Z Dai, W Wu, Z Wang, H Cao… - Frontiers in …, 2021 - frontiersin.org
Gliomas are primary malignant brain tumors. Monocytes have been proved to actively
participate in tumor growth. Weighted gene co-expression network analysis was used to …

Ferroptosis‐Related Gene Signature Promotes Ovarian Cancer by Influencing Immune Infiltration and Invasion

Y You, Q Fan, J Huang, Y Wu, H Lin… - Journal of …, 2021 - Wiley Online Library
Ovarian cancer is a kind of gynecological malignancy with high mortality. Ferroptosis is a
new type of iron‐dependent cell death characterized by the formation of lipid peroxides and …

[HTML][HTML] PDIA3 modulates genomic response to 1, 25-dihydroxyvitamin D3 in squamous cell carcinoma of the skin

JI Nowak, AM Olszewska, A Piotrowska, K Myszczyński… - Steroids, 2023 - Elsevier
An active form of vitamin D 3 (1, 25-dihydroxyvitamin D 3) acts through vitamin D receptor
(VDR) initiating genomic response, but several studies described also non-genomic actions …