Among the age-dependent protein aggregation disorders, nine neurodegenerative diseases
are caused by expansions of CAG repeats encoding polyglutamine (polyQ) tracts. We …

Polyglutamine diseases are a collection of nine CAG trinucleotide expansion disorders,
presenting with a spectrum of neurological and clinical phenotypes. Recent human, mouse …

Niemann–Pick type C disease is a fatal, progressive neurodegenerative disorder caused by
loss-of-function mutations in NPC1, a multipass transmembrane glycoprotein essential for …

Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex
pathological processes, especially the secondary inflammatory cascade and the lack of …

Cerebellar ataxias constitute a heterogeneous group of disorders that result in impaired
speech, uncoordinated limb movements, and impaired balance, often ultimately resulting in …

The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar
ataxia type 2 (SCA2)(a progressive hereditary disease caused by an expansion of …

Abstract Spinocerebellar ataxia type 14 (SCA14) is a subtype of the autosomal dominant
cerebellar ataxias that is characterized by slowly progressive cerebellar dysfunction and …

Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases
mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One …

Background A combination of central muscle relaxants, chlorzoxazone and baclofen
(chlorzoxazone‐baclofen), has been proposed for treatment of cerebellar symptoms in …

Protein kinase C (PKC) isozymes are members of the Serine/Threonine kinase family
regulating cellular events following activation of membrane bound phospholipids. The …