Improved hygiene leading to reduced exposure to microorganisms has been implicated as
one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in …

A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

Multisystem inflammatory syndrome in children (MIS-C) occurs during or recently following
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is …

Gut microbial dysbiosis is associated with the development of autoimmune disease, but the
mechanisms by which microbial dysbiosis affects the transition from asymptomatic …

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory
necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL …

Disruptions in the intestinal epithelial barrier can result in devastating consequences and a
multitude of disease syndromes, particularly among preterm neonates. The association …

Beside digesting nutrients and absorbing solutes and electrolytes, the intestinal epithelium
with its barrier function is in charge of a tightly controlled antigen trafficking from the …

A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries
(Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the …

Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …