Adolescence as a neurobiological critical period for the development of higher-order cognition

B Larsen, B Luna - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …

Rethinking schizophrenia

TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia

DA Lewis, AA Curley, JR Glausier, DW Volk - Trends in neurosciences, 2012 - cell.com
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …

Mechanisms contributing to prefrontal cortex maturation during adolescence

A Caballero, R Granberg, KY Tseng - Neuroscience & Biobehavioral …, 2016 - Elsevier
Adolescence is defined as a transitional period between childhood and adulthood
characterized by changes in social interaction and acquisition of mature cognitive abilities …

Abnormal neural oscillations and synchrony in schizophrenia

PJ Uhlhaas, W Singer - Nature reviews neuroscience, 2010 - nature.com
Converging evidence from electrophysiological, physiological and anatomical studies
suggests that abnormalities in the synchronized oscillatory activity of neurons may have a …

[HTML][HTML] Brain development during adolescence: neuroscientific insights into this developmental period

K Konrad, C Firk, PJ Uhlhaas - Deutsches Ärzteblatt International, 2013 - ncbi.nlm.nih.gov
Background Adolescence is the phase of life between late childhood and adulthood.
Typically, adolescents seek diversion, new experiences, and strong emotions, sometimes …

Development of frontal GABA and glutamate supports excitation/inhibition balance from adolescence into adulthood

MI Perica, FJ Calabro, B Larsen, W Foran… - Progress in …, 2022 - Elsevier
Animal and human postmortem studies provide evidence for changes in gamma-
aminobutyric acid (GABA) and glutamate in prefrontal cortex (PFC) during adolescence …

Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks

PJ Uhlhaas, W Singer - Neuron, 2012 - cell.com
In recent years, numerous studies have tested the relevance of neural oscillations in
neuropsychiatric conditions, highlighting the potential role of changes in temporal …

White matter maturation reshapes structural connectivity in the late developing human brain

P Hagmann, O Sporns, N Madan… - Proceedings of the …, 2010 - National Acad Sciences
From toddler to late teenager, the macroscopic pattern of axonal projections in the human
brain remains largely unchanged while undergoing dramatic functional modifications that …

GABAergic interneuron origin of schizophrenia pathophysiology

K Nakazawa, V Zsiros, Z Jiang, K Nakao, S Kolata… - …, 2012 - Elsevier
Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …