Adolescence as a neurobiological critical period for the development of higher-order cognition
The transition from adolescence to adulthood is characterized by improvements in higher-
order cognitive abilities and corresponding refinements of the structure and function of the …
order cognitive abilities and corresponding refinements of the structure and function of the …
Rethinking schizophrenia
TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …
disabling mental disorder that affects about one per cent of the world's population. After a …
Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
DA Lewis, AA Curley, JR Glausier, DW Volk - Trends in neurosciences, 2012 - cell.com
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory …
Mechanisms contributing to prefrontal cortex maturation during adolescence
A Caballero, R Granberg, KY Tseng - Neuroscience & Biobehavioral …, 2016 - Elsevier
Adolescence is defined as a transitional period between childhood and adulthood
characterized by changes in social interaction and acquisition of mature cognitive abilities …
characterized by changes in social interaction and acquisition of mature cognitive abilities …
Abnormal neural oscillations and synchrony in schizophrenia
PJ Uhlhaas, W Singer - Nature reviews neuroscience, 2010 - nature.com
Converging evidence from electrophysiological, physiological and anatomical studies
suggests that abnormalities in the synchronized oscillatory activity of neurons may have a …
suggests that abnormalities in the synchronized oscillatory activity of neurons may have a …
[HTML][HTML] Brain development during adolescence: neuroscientific insights into this developmental period
Background Adolescence is the phase of life between late childhood and adulthood.
Typically, adolescents seek diversion, new experiences, and strong emotions, sometimes …
Typically, adolescents seek diversion, new experiences, and strong emotions, sometimes …
Development of frontal GABA and glutamate supports excitation/inhibition balance from adolescence into adulthood
Animal and human postmortem studies provide evidence for changes in gamma-
aminobutyric acid (GABA) and glutamate in prefrontal cortex (PFC) during adolescence …
aminobutyric acid (GABA) and glutamate in prefrontal cortex (PFC) during adolescence …
Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks
PJ Uhlhaas, W Singer - Neuron, 2012 - cell.com
In recent years, numerous studies have tested the relevance of neural oscillations in
neuropsychiatric conditions, highlighting the potential role of changes in temporal …
neuropsychiatric conditions, highlighting the potential role of changes in temporal …
White matter maturation reshapes structural connectivity in the late developing human brain
From toddler to late teenager, the macroscopic pattern of axonal projections in the human
brain remains largely unchanged while undergoing dramatic functional modifications that …
brain remains largely unchanged while undergoing dramatic functional modifications that …
GABAergic interneuron origin of schizophrenia pathophysiology
K Nakazawa, V Zsiros, Z Jiang, K Nakao, S Kolata… - …, 2012 - Elsevier
Hypofunction of N-methyl-d-aspartic acid-type glutamate receptors (NMDAR) induced by the
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …
systemic administration of NMDAR antagonists is well known to cause schizophrenia-like …