Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents

MM Morcoss, MN El Shimaa, RA Ibrahem… - Bioorganic …, 2020 - Elsevier
Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1, 2, 4-triazole and
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …

[PDF][PDF] Antioxidant drug design: historical and recent developments

MC Egbujor, SA Egu, VI Okonkwo, AD Jacob… - J. Pharm. Res …, 2021 - researchgate.net
The sustained interest in the design of potent antioxidants drugs over the years can be
attributed to the indispensable roles antioxidants play in the mitigation of oxidative stress …

Design, synthesis, molecular docking and antioxidant evaluation of benzimidazole-1, 3, 4 oxadiazole derivatives

SV Bhandari, OG Nagras, PV Kuthe, AP Sarkate… - Journal of Molecular …, 2023 - Elsevier
In this research, we synthesised novel benzimidazole-1, 3, 4 oxadiazole derivatives and
studied their antioxidant properties using the DPPH Radical Scavenging Assay. A significant …

Synthesis, Spectroscopic and Computational Analysis of 2-[(2-Sulfanyl-1H-benzo[d]imidazol-5-yl)iminomethyl]phenyl Naphthalene-2-sulfonate

G Kotan, H Gökce, O Akyıldırım, H Yüksek… - Russian Journal of …, 2020 - Springer
Abstract 2-[(2-Sulfanyl-1 H-benzo [d] imidazol-5-yl) iminomethyl] phenyl naphthalene-2-
sulfonate was obtained as a result of the reactions of 5-amino-2-sulfanylbenzimidazole with …

Chemistry of biologically active benzimidazole scaffolds: medicinal chemistry perspective

A Bendi, Sangeeta, L Singh… - Mini-Reviews in Organic …, 2022 - benthamdirect.com
Nowadays, heterocyclic compounds have attained a prominent place among the various
classes of aromatic organic compounds. Benzimidazoles are important classes of …

Benzimidazole Derivatives Suppress Fusarium Wilt Disease via Interaction with ERG6 of Fusarium equiseti and Activation of the Antioxidant Defense System of …

A El-Nagar, AA Elzaawely, HM El-Zahaby, TD Xuan… - Journal of Fungi, 2023 - mdpi.com
Sweet pepper (Capsicum annuum L.), also known as bell pepper, is one of the most widely
grown vegetable crops worldwide. It is attacked by numerous phytopathogenic fungi, such …

Novel Benzimidazole/Hydrazone Derivatives as Promising Anticancer Lead Compounds: Design, Synthesis, and Molecular Docking Study

MM Morcoss, ES Abdelhafez… - Journal of advanced …, 2020 - journals.ekb.eg
A novel series of benzimidazole-hydrazone derivatives was designed and synthesized as a
potential anti-cancer agents. The structure of the target compounds was assured using …

Microwave assisted synthesis, biological activities, and in silico investigation of some benzimidazole derivatives

ZA Bhavsar, PT Acharya, DJ Jethava… - Journal of …, 2020 - Wiley Online Library
Some derivatives of 2‐substituted benzimidazole were prepared via coupling of N‐methyl‐o‐
phenylenediamine or o‐phenylenediamine with different aromatic aldehydes catalyzed by …

Assessing the pharmacological potential of selected xanthene derivatives

AM Lazić, AD Mašulović… - Journal of the …, 2023 - technorep.tmf.bg.ac.rs
U ovom radu, predstavljena je jednostavna metoda u dva koraka za sintezu sedam derivata
ksantendiona i jednog derivata ksantenona koji sadrže različite aromatične supstituente …

An efficient protocol for the synthesis of substituted 5‐amino pyrazole bearing benzo [d] imidazolone Core and their antioxidant activity

KN Sanghavi, MN Kher… - Journal of Heterocyclic …, 2023 - Wiley Online Library
An efficient, facile and regioselective route has been utilized for the synthesis of novel series
of 5‐(5‐amino‐1 H‐pyrazol‐3‐yl)‐1, 3‐dimethyl‐1, 3‐dihydro‐2 H‐benzo [d] imidazol‐2 …