Hsp60 is a chaperone belonging to the Chaperonins of Group I and typically functions inside
mitochondria in which, together with the co-chaperonin Hsp10, maintains protein …

Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …

In recent years, with the successful development of proteolysis-targeting chimeric molecules
(PROTACs), the potential of heterobifunctional molecules to contribute to reenvisioning drug …

For decades, reactive persulfide species including cysteine persulfide (CysSSH) have been
known to exist endogenously in organisms. However, the physiological significance of …

Defects in neuronal nitric oxide synthase (nNOS) splice variant localization and signaling in
skeletal muscle are a firmly established pathogenic characteristic of many neuromuscular …

Reactive persulfides such as cysteine persulfide and glutathione persulfide are produced by
bacteria including Salmonella during sulfur metabolism. The biological significance of …

Electrophiles such as methylmercury (MeHg) affect cellular functions by covalent
modification with endogenous thiols. Reactive persulfide species were recently reported to …

Nitroguanosine 3′, 5′-cyclic monophosphate (8-nitro-cGMP) is a unique derivative of
guanosine 3′, 5′-cyclic monophosphate (cGMP) formed in mammalian and plant cells in …

抄録 Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of
biological molecules generated by reactive oxygen species. Current redox biology is …

Maintaining a redox balance by means of precisely controlled systems that regulate
production, and elimination, and metabolism of electrophilic substances (electrophiles) is …