Arrhythmias in pregnancy

KP Tamirisa, U Elkayam, JE Briller, PK Mason… - Clinical …, 2022 - jacc.org
Increasing maternal mortality and incidence of arrhythmias in pregnancy have been noted
over the past 2 decades in the United States. Pregnancy is associated with a greater risk of …

Environmental risk factors for congenital heart disease

JI Kalisch-Smith, N Ved… - Cold Spring Harbor …, 2020 - cshperspectives.cshlp.org
Congenital heart disease (CHD) has many forms and a wide range of causes. Clinically, it is
important to understand the causes. This allows estimation of recurrence rate, guides …

[HTML][HTML] The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

E Azzoni, V Frontera, G Anselmi, C Rode, C James… - Cell reports, 2021 - cell.com
Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the
main embryonic arteries. The onset of circulation triggers several processes that provide …

Modest and severe maternal iron deficiency in pregnancy are associated with fetal anaemia and organ-specific hypoxia in rats

AG Woodman, AS Care, Y Mansour, SJ Cherak… - Scientific reports, 2017 - nature.com
Prenatal iron-deficiency (ID) is known to alter fetal developmental trajectories, which
predisposes the offspring to chronic disease in later life, although the underlying …

Early gestational hypoxia and adverse developmental outcomes

HE Ritchie, DJ Oakes, D Kennedy… - Birth Defects …, 2017 - Wiley Online Library
Hypoxia is a normal and essential part of embryonic development. However, this state may
leave the embryo vulnerable to damage when oxygen supply is disturbed. Embryofetal …

Ondansetron and teratogenicity in rats: Evidence for a mechanism mediated via embryonic hERG blockade

B Danielsson, WS Webster, HE Ritchie - Reproductive Toxicology, 2018 - Elsevier
The potent hERG channel blocking drug ondansetron is used off-label for treatment of
nausea and vomiting in early pregnancy. Some human epidemiological studies have …

Effects of pre-and postnatal exposure to 1880–1900 MHz DECT base radiation on development in the rat

M Stasinopoulou, AF Fragopoulou, A Stamatakis… - Reproductive …, 2016 - Elsevier
In the present study, to evaluate the effects of wireless 1880–1900 MHz Digital Enhanced
Communication Telephony (DECT) base radiation on fetal and postnatal development …

[HTML][HTML] Antiarrhythmic Drug Use in Pregnancy: Considerations and Safety Profiles

MV Mariani, N Pierucci, VM La Fazia… - Journal of …, 2024 - mdpi.com
Pregnancy entails notable physiological alterations and hormonal fluctuations that affect the
well-being of both the fetus and the mother. Cardiovascular events and arrhythmias are a …

The effects of nifedipine and ivabradine on the functionality of the early rat embryonic heart. Are these drugs a risk in early human pregnancy?

HE Ritchie, C Telenius, E Gustaffson… - Birth Defects …, 2019 - Wiley Online Library
Background When the human heart begins its earliest contractions from day 21, it lacks a
functional autonomic nerve supply. Instead, contractions are generated by regular calcium …

The effect of phenytoin on embryonic heart rate in Vivo

HE Ritchie, D Abela, D Ababneh, AM Howe… - Reproductive …, 2021 - Elsevier
Phenytoin is a known human teratogen with unknown etiology. Several mechanisms have
been proposed including disturbances in folate metabolism, induction of embryonic hypoxia …