Severe hemorrhage is a leading cause of high mortality in critical situations like disaster,
accidents, and warfare. The resulting wounds could induce severe physical and …

Bioadhesives have demonstrated their superiority in clinical applications as tissue
adhesives, hemostats, and tissue sealants. Because of the intrinsic stickiness, the …

Background Efficient and stable delivery of neurotrophic factors (NTFs) is crucial to provide
suitable microenvironment for peripheral nerve regeneration. Neurotrophin-3 (NT-3) is an …

Biomaterials can modulate the local immune and repair-supportive microenvironments to
promote peripheral nerve regeneration. Inorganic bioceramics have been widely used for …

Nerve guidance conduits with multifunctional features could offer microenvironments for
improved nerve regeneration and functional recovery. However, the challenge remains to …

Background Silent information regulator 6 (SIRT6) is a mammalian homolog of the
nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior …

Development of multifunctional tube-filling materials is required to improve the performances
of the existing nerve guidance conduits (NGCs) in the repair of long-gap peripheral nerve …

Background Plenty of macrophages are recruited to the injured nerve to play key roles in the
immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian …

Lithium (Li), a widely used drug for bipolar disorder management, is associated with many
side effects due to systemic exposure. The localized delivery of lithium through implants …

Nerve guide conduits (NGCs) offer a promising alternative to traditional tools for
regenerating peripheral nerves. The efficacy of nerve regeneration and functional recovery …