Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Ophidian envenomation is an important health problem in Brazil and other South American
countries. In folk medicine, especially in developing countries, several vegetal species are …

The blood plasma of numerous snake species naturally comprises endogenous
phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may …

Interest in studies on the neutralization of snake venoms and toxins by diverse types of
inhibitors is two-fold. From an applied perspective, results enclose the potential to be …

Natural inhibitors occupy an important place in the potential to neutralize the toxic effects
caused by snake venom proteins and enzymes. It has been well recognized for several …

Phospholipases A2 (PLA2) are enzymes acting on the cell membrane phospholipids
resulting in fatty acids and lysophospholipids and deconstructing the cell membrane. This …

Phospholipases A2 (PLA2s) from snake venoms comprise a group of 14-18 kDa proteins,
responsible for several toxic effects induced by the whole venom. Considering this, studies …

Crotoxin, a phospholipase A 2 (PLA 2) complex and the major Crotalus venom component,
is responsible for the main symptoms described in crotalic snakebite envenomings and a …

In the present work, we describe the isolation and partial structural and biochemical
characterization of the first phospholipase A 2 inhibitor (γPLI) from Crotalus durissus …

The use of venom in predation exerts a corresponding selection pressure for the evolution of
venom resistance. One of the mechanisms related to venom resistance in animals …