[HTML][HTML] Pros and cons of different therapeutic antibody formats for recombinant antivenom development

AH Laustsen, JM Gutiérrez, C Knudsen, KH Johansen… - Toxicon, 2018 - Elsevier
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by
the many advances in immunology, synthetic biology, and antibody research, different …

Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa

DJ Williams, JM Gutiérrez, JJ Calvete, W Wüster… - Journal of …, 2011 - Elsevier
The development of snake antivenoms more than a century ago should have heralded
effective treatment of the scourge of snakebite envenoming in impoverished, mostly rural …

Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: State-of-the-art and challenges ahead

JM Gutiérrez, G Solano, D Pla, M Herrera, Á Segura… - Toxins, 2017 - mdpi.com
Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming.
The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to …

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability …

JJ Calvete, L Sanz, A Pérez, A Borges, AM Vargas… - Journal of …, 2011 - Elsevier
We describe two geographically differentiated venom phenotypes across the wide
distribution range of Bothrops atrox, from the Colombian Magdalena Medio Valley through …

Bleeding and Thrombosis: Insights into Pathophysiology of Bothrops Venom-Related Hemostasis Disorders

S Larréché, JP Chippaux, L Chevillard… - International Journal of …, 2021 - mdpi.com
Toxins from Bothrops venoms targeting hemostasis are responsible for a broad range of
clinical and biological syndromes including local and systemic bleeding, incoagulability …

Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of Bothrops complex

LF Sousa, CA Nicolau, PS Peixoto… - PLoS neglected …, 2013 - journals.plos.org
In Latin America, Bothrops snakes account for most snake bites in humans, and the
recommended treatment is administration of multispecific Bothrops antivenom (SAB–soro …

Antivenoms for the treatment of snakebite envenomings: the road ahead

JM Gutiérrez, G León, T Burnouf - Biologicals, 2011 - Elsevier
The parenteral administration of antivenoms is the cornerstone of snakebite envenoming
therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are …

New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India

DA Warrell, JM Gutiérrez, JJ Calvete… - Indian Journal of …, 2013 - journals.lww.com
The direct estimate of 46,000 snakebite deaths in India in 2005 (1 for every 2 HIV/AIDS
deaths), based on verbal autopsies, renders unrealistic the total of only 47,000 snakebite …

Priority actions and progress to substantially and sustainably reduce the mortality, morbidity and socioeconomic burden of tropical snakebite

RA Harrison, JM Gutiérrez - 2016 - mdpi.com
The deliberations and conclusions of a Hinxton Retreat convened in September 2015,
entitled “Mechanisms to reverse the public health neglect of snakebite victims” are reported …

[HTML][HTML] Envenenamientos por mordeduras de serpientes en América Latina y el Caribe: Una visión integral de carácter regional

JM Gutiérrez - Boletín de malariología y salud ambiental, 2011 - ve.scielo.org
Se analiza la situación de los envenenamientos por mordeduras de serpiente en América
Latina y el Caribe, los cuales representan un importante problema de Salud Pública en la …