Gut microbial metabolites as multi-kingdom intermediates
KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …
metabolites. These metabolites exert their effects within the host as signalling molecules and …
The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer
L Sun, J Cai, FJ Gonzalez - Nature Reviews Gastroenterology & …, 2021 - nature.com
Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …
Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …
Secondary bile acids and short chain fatty acids in the colon: a focus on colonic microbiome, cell proliferation, inflammation, and cancer
H Zeng, S Umar, B Rust, D Lazarova… - International journal of …, 2019 - mdpi.com
Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …
Dietary fat, bile acid metabolism and colorectal cancer
S Ocvirk, SJD O'Keefe - Seminars in cancer biology, 2021 - Elsevier
Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …
Guts and gall: bile acids in regulation of intestinal epithelial function in health and disease
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …
Dietary factors modulating colorectal carcinogenesis
F Vernia, S Longo, G Stefanelli, A Viscido, G Latella - Nutrients, 2021 - mdpi.com
The development of colorectal cancer, responsible for 9% of cancer-related deaths, is
favored by a combination of genetic and environmental factors. The modification of diet and …
favored by a combination of genetic and environmental factors. The modification of diet and …
[HTML][HTML] Bile acid nuclear receptor FXR and digestive system diseases
L Ding, L Yang, Z Wang, W Huang - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Bile acids (BAs) are not only digestive surfactants but also important cell signaling
molecules, which stimulate several signaling pathways to regulate some important …
molecules, which stimulate several signaling pathways to regulate some important …
Cervical cancer, different treatments and importance of bile acids as therapeutic agents in this disease
T Šarenac, M Mikov - Frontiers in Pharmacology, 2019 - frontiersin.org
Cervical cancer can be cured, because it has a long preinvasive period. Early diagnosis and
treatment of cervical cancer at women are crucial for reducing of rate mortality. Today, there …
treatment of cervical cancer at women are crucial for reducing of rate mortality. Today, there …
The gut microbiota at the intersection of bile acids and intestinal carcinogenesis: an old story, yet mesmerizing
T Liu, X Song, S Khan, Y Li, Z Guo, C Li… - … journal of cancer, 2020 - Wiley Online Library
The prevalence of colorectal cancer (CRC) has markedly increased worldwide in the last
decade. Alterations of bile acid metabolism and gut microbiota have been reported to play …
decade. Alterations of bile acid metabolism and gut microbiota have been reported to play …