The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

Farnesoid X receptor (FXR) is a ligand-activated transcription factor involved in the control of
bile acid (BA) synthesis and enterohepatic circulation. FXR can influence glucose and lipid …

Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

Secondary bile acids (BAs) and short chain fatty acids (SCFAs), two major types of bacterial
metabolites in the colon, cause opposing effects on colonic inflammation at chronically high …

Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs
where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and …

The development of colorectal cancer, responsible for 9% of cancer-related deaths, is
favored by a combination of genetic and environmental factors. The modification of diet and …

Bile acids (BAs) are not only digestive surfactants but also important cell signaling
molecules, which stimulate several signaling pathways to regulate some important …

Cervical cancer can be cured, because it has a long preinvasive period. Early diagnosis and
treatment of cervical cancer at women are crucial for reducing of rate mortality. Today, there …

The prevalence of colorectal cancer (CRC) has markedly increased worldwide in the last
decade. Alterations of bile acid metabolism and gut microbiota have been reported to play …