Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma

MA Abd-Elmawla, SSA Mageed… - … -Research and Practice, 2023 - Elsevier
Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer
characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable …

Clinical development of TargomiRs, a miRNA mimic-based treatment for patients with recurrent thoracic cancer

G Reid, SC Kao, N Pavlakis, H Brahmbhatt… - …, 2016 - Taylor & Francis
miRNAs are responsible for post-transcriptional control of gene expression, and are
frequently downregulated in cancer. It has become well established that restoring miRNA …

[HTML][HTML] Tumor suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

SC Kao, YY Cheng, M Williams, MB Kirschner… - Journal of Thoracic …, 2017 - Elsevier
Introduction The upregulation of programmed death ligand 1 (PD-L1) is found in many
cancers and contributes to evasion of the host's immune defense. In malignant pleural …

Tumor‐suppressive microRNA‐223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer

A Kurozumi, Y Goto, R Matsushita, I Fukumoto… - Cancer …, 2016 - Wiley Online Library
Analysis of micro RNA (mi RNA) expression signatures in prostate cancer (PC a) and
castration‐resistant PC a has revealed that mi RNA‐223 is significantly downregulated in …

[HTML][HTML] Roles of microRNAs in inflammatory bowel disease

HT Jung, JS Kim, KH Lee, K Tizaoui… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract that mainly affects young people. IBD is associated with various gastrointestinal …

Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers

J Liu, J Li, K Wang, H Liu, J Sun, X Zhao, Y Yu… - Signal transduction and …, 2021 - nature.com
Fork-head box protein M1 (FoxM1) is a transcriptional factor which plays critical roles in
cancer development and progression. However, the general regulatory mechanism of …

Cytoskeleton and associated proteins: pleiotropic JNK substrates and regulators

B Benoit, A Baillet, C Poüs - International journal of molecular sciences, 2021 - mdpi.com
This review extensively reports data from the literature concerning the complex relationships
between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton …

[HTML][HTML] Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis

L Micolucci, MM Akhtar, F Olivieri, MR Rippo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Background Asbestos is a harmful and exceptionally persistent natural material. Malignant
mesothelioma (MM), an asbestos-related disease, is an insidious, lethal cancer that is poorly …

The role of autophagy and related microRNAs in inflammatory bowel disease

S Wang, Y Huang, C Zhou, H Wu… - Gastroenterology …, 2018 - Wiley Online Library
Accumulating evidence demonstrates that microRNA‐(miR‐) mediated posttranscriptional
regulation plays an important role in autophagy in inflammatory bowel disease (IBD), a …

The role of miRNA-223 in cancer: Function, diagnosis and therapy

Y Gao, L Lin, T Li, J Yang, Y Wei - Gene, 2017 - Elsevier
MicroRNAs (miRNAs) constitute a large family of small, non-coding RNAs with the capacity
to regulate gene expression post-transcriptionally. miRNAs appear to hold promise of …