[HTML][HTML] Introduction to metabolomics and its applications in ophthalmology

SZ Tan, P Begley, G Mullard, KA Hollywood, PN Bishop - Eye, 2016 - nature.com
Metabolomics is the study of endogenous and exogenous metabolites in biological systems,
which aims to provide comparative semi-quantitative information about all metabolites in the …

Unifying mechanism for eye toxicity: electron transfer, reactive oxygen species, antioxidant benefits, cell signaling and cell membranes

P Kovacic, R Somanathan - Cell membranes and free radical …, 2008 - dergipark.org.tr
Eye toxicity comprises an important part in the category of insults to major organs. There is
considerable literature comprising industrial chemicals, atmospheric pollutants, metals …

Quantification of metabolites in breast cancer patients with different clinical prognosis using HR MAS MR spectroscopy

B Sitter, TF Bathen, TE Singstad… - NMR in Biomedicine …, 2010 - Wiley Online Library
Absolute quantitative measures of breast cancer tissue metabolites can increase our
understanding of biological processes. Electronic REference To access In vivo …

[HTML][HTML] In vitro model suggests oxidative stress involved in keratoconus disease

D Karamichos, AEK Hutcheon, CB Rich… - Scientific reports, 2014 - nature.com
Abstract Keratoconus (KC) affects 1: 2000 people and is a disorder where cornea thins and
assumes a conical shape. Advanced KC requires surgery to maintain vision. The role of …

Tear metabolite changes in keratoconus

D Karamichos, JD Zieske, H Sejersen… - Experimental eye …, 2015 - Elsevier
While efforts have been made over the years, the exact cause of keratoconus (KC) remains
unknown. The aim of this study was to identify alterations in endogenous metabolites in the …

Metabolomic composition of normal aged and cataractous human lenses

YP Tsentalovich, TD Verkhovod, VV Yanshole… - Experimental eye …, 2015 - Elsevier
Quantitative metabolomic profiles of normal and cataractous human lenses were obtained
with the combined use of high-frequency nuclear magnetic resonance (NMR) and high …

Metabolomics of the rat lens: A combined LC-MS and NMR study

VV Yanshole, OA Snytnikova, AS Kiryutin… - Experimental eye …, 2014 - Elsevier
This work is the first comprehensive report on the quantitative metabolomic composition of
the rat lens. Quantitative metabolomic profiles of lenses were acquired with the combined …

Aggregation of α-crystallins in kynurenic acid-sensitized UVA photolysis under anaerobic conditions

PS Sherin, EA Zelentsova, ED Sormacheva… - Physical Chemistry …, 2016 - pubs.rsc.org
The reactions of photoexcited kynurenic acid (KNA) with bovine α-crystallins under
anaerobic conditions proceed via the electron transfer from tryptophan (Trp) and tyrosine …

[HTML][HTML] Prevention of UV-induced damage to the anterior segment using class I UV-absorbing hydrogel contact lenses

HL Chandler, KS Reuter, LT Sinnott… - … & visual science, 2010 - tvst.arvojournals.org
Purpose.: To determine whether class I ultraviolet (UV) light–blocking contact lenses prevent
UV-induced pathologic changes in a rabbit model. Methods.: Twelve rabbits were assigned …

[HTML][HTML] Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts

C Frankfater, SL Bozeman, FF Hsu, UP Andley - PloS one, 2020 - journals.plos.org
Cataracts are a major cause of blindness worldwide and commonly occur in individuals over
70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens …