Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs
S Janowska, S Holota, R Lesyk, M Wujec - Molecules, 2024 - mdpi.com
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are
hormones that contribute to the growth of certain types of breast cancer. In particular …
hormones that contribute to the growth of certain types of breast cancer. In particular …
Aromatase inhibitors for the treatment of breast cancer: An overview (2019–2023)
N Bhatia, S Thareja - Bioorganic Chemistry, 2024 - Elsevier
Aromatase inhibition is considered a legitimate approach for the treatment of ER-positive
(ER+) breast cancer as it accounts for more than 70% of breast cancer cases. Aromatase …
(ER+) breast cancer as it accounts for more than 70% of breast cancer cases. Aromatase …
[HTML][HTML] Molecular modeling and DFT studies of diazenylphenyl derivatives as a potential HBV and HCV antiviral agents
The need for novel antiviral drug particularly for hepatitis B (HBV) and C (HCV) virus cannot
be over emphasized hence, this work focuses on the stability and intermolecular interaction …
be over emphasized hence, this work focuses on the stability and intermolecular interaction …
Machine learning-assisted prediction of the biological activity of aromatase inhibitors and data mining to explore similar compounds
Designing molecules for drugs has been a hot topic for many decades. However, it is hard
and expensive to find a new molecule. Thus, the cost of the final drug is also increased …
and expensive to find a new molecule. Thus, the cost of the final drug is also increased …
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
ST Sudevan, JM Oh, MA Abdelgawad… - Scientific reports, 2022 - nature.com
The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
Synthesis, characterization, molecular dynamic simulation, and biological assessment of cinnamates linked to imidazole/benzimidazole as a CYP51 inhibitor
Abstract A class of 2-(1 H-imidazol-1-yl)-1-phenylethyl cinnamates 6a-6j and 2-(1 H-benzo
[d] imidazol-1-yl)-1-phenylethyl cinnamates 7a-7j were synthesized, and their synthesis was …
[d] imidazol-1-yl)-1-phenylethyl cinnamates 7a-7j were synthesized, and their synthesis was …
Synthesis and Anticancer Activity of Novel Derivatives of α,β‐Unsaturated Ketones Based on Oleanolic Acid: in Vitro and in Silico Studies against Prostate Cancer …
H Şenol, M Ghaffari‐Moghaddam, Ş Bulut… - Chemistry & …, 2023 - Wiley Online Library
Herein, new derivatives of α, β‐unsaturated ketones based on oleanolic acid (4 a–i) were
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
Evaluation of oxindole derivatives as a potential anticancer agent against breast carcinoma cells: In vitro, in silico, and molecular docking study
In this study we have performed the in vitro anticancer activity of spiro oxindole derivatives
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …
against MCF-7 (human Adreno carcinoma) and MDA-MB-231 (triple negative breast cancer) …
Novel chalcone derivatives of ursolic acid as acetylcholinesterase inhibitors: Synthesis, characterization, biological activity, ADME prediction, molecular docking and …
Acetylcholinesterase (AChE) is a critical target in the prevention of Alzheimer's Disease (AD)
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
Development of isopropyl-tailed chalcones as a new class of selective MAO-B inhibitors for the treatment of Parkinson's disorder
S Kumar, JM Oh, MA Abdelgawad, MAS Abourehab… - ACS …, 2023 - ACS Publications
Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …