Chemical protein modification has emerged as an invaluable tool for the development of
modified proteins. The complementary use of both genetic and chemical methods has …

There is a growing need for biocompatible click reactions in order to prepare multifunctional
conjugates, which are valuable molecules for innovative biomedical applications. In this …

Binding via reversible covalent bond formation presents a novel and powerful mechanism to
enhance the potency of synthetic inhibitors for therapeutically important proteins. Work on …

Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …

Viruses are changing the biosensing and biomedicine landscape due to their multivalency,
orthogonal reactivities, and responsiveness to genetic modifications. As the most extensively …

Chemoselective ligation reactions have contributed immensely to the development of
organic synthesis and chemical biology. However, the ligation of stoichiometric amounts of …

Genetically encoded macrocyclic peptide libraries with unnatural pharmacophores are
valuable sources for the discovery of ligands for many targets of interest. Traditionally …

Highlights•Display techniques allow the genetic encoding and screening of billions of
peptides.•Strategies were developed to chemically modify genetically encoded peptide …

Bacteriophages (phages) represent a unique category of viruses with a remarkable ability to
selectively infect host bacteria, characterized by their assembly from proteins and nucleic …

Biosensors have been explored for their excellent potential in the field of biological detection
and their application in biomedical diagnosis and have become a rapidly emerging subject …