Therapeutic drug monitoring (TDM) of immunosuppressive drugs (ISDs) with a narrow
therapeutic index is an increasingly popular tool for minimizing drug toxicity while …

Background Immunosuppressive drugs (ISD) are an essential tool in the treatment of
transplant rejection and immune-mediated diseases. Therapeutic drug monitoring (TDM) for …

Tacrolimus is a macrolide immunosuppressant widely used in organ transplantation. Due to
the narrow treatment window, therapeutic drug monitoring of the clinical application of …

Immunosuppressant drugs (ISDs) play a key role in short-term patient survival together with
very low acute allograft rejection rates in transplant recipients. Due to the narrow therapeutic …

The transplantation of a solid organ is always followed by a lifelong immunosuppressive
therapy to guarantee the survival of the organ in the recipient. Immunosuppressive drugs …

Pharmacokinetics, biodistribution, and biological activity are key parameters that determine
the success or failure of therapeutics. Many developments intended to improve their in vivo …

Fluorescence immunoassays are popular for achieving high sensitivity, but they display
limitations in biological samples due to strong absorption of light, background fluorescence …

Intrinsically disordered proteins, such as tau or α-synuclein, have long been associated with
a dysfunctional role in neurodegenerative diseases. In Alzheimer's and Parkinson's' …

The use of infliximab has completely changed the therapeutic landscape in inflammatory
bowel disease. However, despite its proven efficacy to induce and maintain clinical …

Background Therapeutic drug monitoring (TDM) systems generally use either liquid
chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both …