Solid lipid nanoparticles and nanostructured lipid carriers: A review of the methods of manufacture and routes of administration
The bioavailability of drugs is dependent on several factors such as solubility and the
administration route. A drug with poor aqueous solubility, therefore, poses challenges with …
administration route. A drug with poor aqueous solubility, therefore, poses challenges with …
Pharmacokinetics and pharmacodynamics of intranasal solid lipid nanoparticles and nanostructured lipid carriers for nose-to-brain delivery
TTL Nguyen, HJ Maeng - Pharmaceutics, 2022 - mdpi.com
Nose-to-brain drug delivery has been of great interest for the treatment of many central
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …
Nose to brain delivery of donepezil through surface modified NLCs: Formulation development, optimization, and brain targeting study
M Yasir, A Zafar, KM Noorulla, AJ Tura… - Journal of Drug Delivery …, 2022 - Elsevier
The research was aimed to formulate the Donepezil (DPZ)-loaded nanostructured lipid
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …
Statistically designed dexibuprofen loaded solid lipid nanoparticles for enhanced oral bioavailability
Abstract Dexibuprofen (DBPN), a non-steroidal anti-inflammatory drug (NSAID), exhibit its
action by inhibiting COX enzymes. It belongs to BCS class Ⅱ drugs, owing to its poor …
action by inhibiting COX enzymes. It belongs to BCS class Ⅱ drugs, owing to its poor …
Recent advances in intranasal administration for brain-targeting delivery: a comprehensive review of lipid-based nanoparticles and stimuli-responsive gel formulations
J Koo, C Lim, KT Oh - International Journal of Nanomedicine, 2024 - Taylor & Francis
Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
Development of atomoxetine-loaded NLC in situ gel for nose-to-brain delivery: optimization, in vitro, and preclinical evaluation
The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …
Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery
AC Correia, JN Moreira, JM Sousa Lobo… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route
V Gattani, S Dawre - Journal of drug delivery science and technology, 2023 - Elsevier
In 2019 the emergence of SARS-COV-2 caused pandemic situation worldwide and
claimed∼ 6.4 M lives (WHO 2022). Favipiravir (FAV) is recommended as a therapy for Covid …
claimed∼ 6.4 M lives (WHO 2022). Favipiravir (FAV) is recommended as a therapy for Covid …
Biomaterials-enhanced intranasal delivery of drugs as a direct route for brain targeting
E Marcello, V Chiono - International Journal of Molecular Sciences, 2023 - mdpi.com
Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …
[HTML][HTML] Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced …
In the past, curcumin was the go-to medication for diabetes, but recent studies have shown
that tetrahydrocurcumin is more effective. The problem is that it's not very soluble in water or …
that tetrahydrocurcumin is more effective. The problem is that it's not very soluble in water or …