Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Abstract Phelan‐McDermid syndrome (PMS, OMIM# 606232), also known as chromosome
22q13 deletion syndrome, is a rare genetic disorder characterized by intellectual disability …

Chronic allograft dysfunction (CAD), characterized histologically by interstitial fibrosis and
tubular atrophy, is the major cause of kidney allograft loss. Here, using single nuclei RNA …

Oriented cell division (OCD) and convergent extension (CE) shape developing renal
tubules, and their disruption has been associated with polycystic kidney disease (PKD) …

The phenomenon of planar cell polarity is critically required for a myriad of morphogenetic
processes in metazoan and is accurately controlled by several conserved modules. Six …

The molecular complexes underlying planar cell polarity (PCP) were first identified in
Drosophila through analysis of mutant phenotypes in the adult cuticle and the orientation of …

The planar cell polarity (PCP) pathway controls a variety of morphological events across
many species. During embryonic development, the PCP pathway regulates coordinated …

Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific
lymphatic function. Little is known about lymphatics in the developing kidney, despite their …

CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals
from eleven independent families with bi-allelic variants in CELSR3. Affected individuals …

Tumor invasion underlies further metastasis, the leading cause for cancer-related deaths.
Deregulation of microRNAs has been identified associated with the malignant behavior of …