[HTML][HTML] Non-coding RNAs as regulators in epigenetics

JW Wei, K Huang, C Yang… - Oncology reports, 2017 - spandidos-publications.com
Epigenetics is a discipline that studies heritable changes in gene expression that do not
involve altering the DNA sequence. Over the past decade, researchers have shown that …

HOTAIR LncRNA: a novel oncogenic propellant in human cancer

T Rajagopal, S Talluri, RL Akshaya, NR Dunna - Clinica chimica acta, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) are an important novel class of non-coding RNAs having
lengths of 200 nucleotides and low expression. The HOX Transcript Antisense Intergenic …

Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2

Q Chen, J Cai, Q Wang, Y Wang, M Liu, J Yang… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Long noncoding RNAs have been implicated in gliomagenesis, but their
mechanisms of action are mainly undocumented. Through public glioma mRNA expression …

[HTML][HTML] LncRNA HOTAIR is a prognostic biomarker for the proliferation and chemoresistance of colorectal cancer via MiR-203a-3p-mediated Wnt/ss-catenin signaling …

Z Xiao, Z Qu, Z Chen, Z Fang, K Zhou… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: HOX transcript antisense RNA (HOTAIR) plays a vital role in
carcinogenesis. However, its functional and regulatory roles remain unclear. In this study …

Gas5 exerts tumor-suppressive functions in human glioma cells by targeting miR-222

X Zhao, P Wang, J Liu, J Zheng, Y Liu, J Chen, Y Xue - Molecular Therapy, 2015 - cell.com
Aberrant expression of noncoding RNAs in glioma cells, including long noncoding RNAs
(lncRNAs) and microRNAs, may participate in the progression of glioma. Encoded by …

A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma

Q Wang, J Zhang, Y Liu, W Zhang, J Zhou, R Duan… - Cancer letters, 2016 - Elsevier
The comprehensive lncRNA expression signature in glioma has not yet been fully
elucidated. We performed a high-throughput microarray to detect the ncRNA expression …

Long noncoding RNAs regulate cell growth, proliferation, and apoptosis

J Li, H Tian, J Yang, Z Gong - DNA and cell biology, 2016 - liebertpub.com
The revolutionary findings in nonprotein-coding part of human genome analysis have
revealed a large number of RNA transcripts longer than 200 nucleotides that lack coding …

LncRNAs associated with glioblastoma: from transcriptional noise to novel regulators with a promising role in therapeutics

B Yadav, S Pal, Y Rubstov, A Goel, M Garg… - … Therapy-Nucleic Acids, 2021 - cell.com
Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in
adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially …

EMT‐and MET‐related processes in nonepithelial tumors: importance for disease progression, prognosis, and therapeutic opportunities

UD Kahlert, JV Joseph, FAE Kruyt - Molecular oncology, 2017 - Wiley Online Library
The epithelial‐to mesenchymal (EMT) process is increasingly recognized for playing a key
role in the progression, dissemination, and therapy resistance of epithelial tumors …

lncRNA HOTAIR contributes to 5FU resistance through suppressing miR-218 and activating NF-κB/TS signaling in colorectal cancer

P Li, X Zhang, L Wang, L Du, Y Yang, T Liu, C Li… - … Therapy-Nucleic Acids, 2017 - cell.com
One major reason for the failure of advanced colorectal cancer (CRC) treatment is the
occurrence of chemoresistance to fluoropyrimidine (FU)-based chemotherapy. Long non …