As immunogenic cell death (ICD) inducers initiating antitumor immune responses, certain
chemotherapeutic drugs have shown considerable potential to reverse the …

The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

We have profiled, for the first time, an evolving human metastatic microenvironment by
measuring gene expression, matrisome proteomics, cytokine and chemokine levels …

Many fields in chemical biology and synthetic biology require effective bioconjugation
methods to achieve their desired functions and activities. Among such biomolecule …

Cytotoxic lymphocytes are critical in our immune defence against cancer and infection.
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …

Tumor cells have the ability to induce platelet activation and aggregation. This has been
documented to be involved in tumor progression in several types of cancers, such as lung …

Curing cancer has drastically improved in recent decades, but it is essential to find more
effective and specific treatments. Radiotherapy and chemotherapy can cause serious side …

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing
to their exquisite features, such as excellent textural properties or biocompatibility. However …

Cathepsins (Caths) are lysosomal proteases that participate in various physiological and
pathological processes. Accumulating evidence suggests that caths play a multifaceted role …

Three different multifunctional nanosystems based on the tethering onto mesoporous silica
nanoparticles (MSN) of different fragments such as an organotin-based cytotoxic compound …