Characterization of G-quadruplexes folding/unfolding dynamics and interactions with proteins from single-molecule force spectroscopy

Y Cheng, Y Zhang, H You - Biomolecules, 2021 - mdpi.com
G-quadruplexes (G4s) are stable secondary nucleic acid structures that play crucial roles in
many fundamental biological processes. The folding/unfolding dynamics of G4 structures …

Catalytic Relaxation of Kinetically Trapped Intermediates by DNA Chaperones

P Pokhrel, D Karna, S Jonchhe… - Journal of the American …, 2024 - ACS Publications
Common in biomacromolecules, kinetically trapped misfolded intermediates are often
detrimental to the structures, properties, or functions of proteins or nucleic acids. Nature …

Proximal single-stranded RNA destabilizes human telomerase RNA G-quadruplex and induces its distinct conformers

S Ye, Z Chen, X Zhang, F Li, L Guo… - The Journal of …, 2021 - ACS Publications
Single-stranded guanine-rich RNA sequences have a propensity to fold into compact G-
quadruplexes (RG4s). The conformational transitions of these molecules provide an …

[PDF][PDF] Matemáticas de la Materia Viva

JR Arias-Gonzalez - lifehub.csic.es
We present a thermodynamic theory for material chains made up of nanoscopic subunits
with symbolic meaning in the presence of memory. This framework is based on the …