There is a longstanding association between substance-use disorders (SUDs) and the
psychological construct of impulsivity. In the first section of this review, personality and …

Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

BackgroundIndividuals with cocaine and gambling addictions exhibit cognitive flexibility
deficits that may underlie persistence of harmful behaviours. AimsWe investigated the neural …

Abnormal behaviors involving dopaminergic gene polymorphisms often reflect an
insufficiency of usual feelings of satisfaction, or Reward Deficiency Syndrome (RDS). RDS …

Background Heroin dependence is a debilitating psychiatric disorder with complex
inheritance. Since the dopaminergic system has a key role in rewarding mechanism of the …

The Taq IA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene
that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 …

Studies of gene-environment interplay typically focus on one environmental factor at a time,
resulting in a constrained view of social context. The concept of environmental contingency …

Abstract Background and Hypothesis: It is well known that after prolonged abstinence,
individuals who use their drug of choice experience a powerful euphoria that often …

Several studies have assessed the association between genetic polymorphisms of DRD2
and DRD4 genes and opioid dependence risk, while the results were inconsistent. We …

Since 1990, when our laboratory published the association of the DRD2 Taq A1 allele and
severe alcoholism in JAMA, there has been an explosion of genetic candidate association …