Human NK cells: surface receptors, inhibitory checkpoints, and translational applications
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
cope with various pathogens present in the vicinity of environmental surroundings inhabited …
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
Pediatric coronavirus disease 2019 (COVID-19) after SARS-CoV-2 infection is associated
with fewer hospitalizations and often milder disease than in adults. A subset of children …
with fewer hospitalizations and often milder disease than in adults. A subset of children …
[HTML][HTML] NK cells and ILCs in tumor immunotherapy
Cells of the innate immunity play an important role in tumor immunotherapy. Thus, NK cells
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
can control tumor growth and metastatic spread. Thanks to their strong cytolytic activity …
Cell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth
Developing effective immunotherapies with low toxicity and high tumor specificity is the
ultimate goal in the battle against cancer. Here, we reported a cell-membrane …
ultimate goal in the battle against cancer. Here, we reported a cell-membrane …
Human NK cells, their receptors and function
L Quatrini, M Della Chiesa, S Sivori… - European journal of …, 2021 - Wiley Online Library
NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of
defense against viral infections and contribute to control tumor growth and metastasis. Their …
defense against viral infections and contribute to control tumor growth and metastasis. Their …
[HTML][HTML] Immunobiography and the heterogeneity of immune responses in the elderly: a focus on inflammaging and trained immunity
Owing to its memory and plasticity, the immune system (IS) is capable of recording all the
immunological experiences and stimuli it was exposed to. The combination of type, dose …
immunological experiences and stimuli it was exposed to. The combination of type, dose …
[HTML][HTML] Functions of natural killer cells
E Vivier, E Tomasello, M Baratin, T Walzer… - Nature …, 2008 - nature.com
Natural killer (NK) cells are effector lymphocytes of the innate immune system that control
several types of tumors and microbial infections by limiting their spread and subsequent …
several types of tumors and microbial infections by limiting their spread and subsequent …
Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances
Chemotherapeutic agents have certain limitations when it comes to treating cancer, the most
important being severe side effects along with multidrug resistance developed against them …
important being severe side effects along with multidrug resistance developed against them …
[HTML][HTML] Leveraging NKG2D ligands in immuno-oncology
Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …
new avenues towards the development of novel assets to achieve durable immune control …